FOG04213
EOG82280W
sce:TPM1;TPM2
Genes: 30
EOG82280W
sce:TPM1;TPM2
Genes: 30
SGD Description
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication|Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication
PomBase Description
tropomyosin
AspGD Description
Tropomyosin
References
Nurse P, et al. (1976 Jul 23). Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.
Streiblová E, et al. (1984 Jul). Septum pattern in ts mutants of Schizosaccharomyces pombe defective in genes cdc3, cdc4, cdc8 and cdc12.
Liu HP, et al. (1989 Apr 21). Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton.
Balasubramanian MK, et al. (1992 Nov 5). A new tropomyosin essential for cytokinesis in the fission yeast S. pombe.
Drees B, et al. (1995 Feb). Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.
Balasubramanian MK, et al. (1996 Dec 2). Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function.
Chang F, et al. (1996 Jan). Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring.
Chang F, et al. (1997 Apr 7). cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin.
Motegi F, et al. (1997 Dec 29). Identification of Myo3, a second type-II myosin heavy chain in the fission yeast Schizosaccharomyces pombe.
Arai R, et al. (1998 Aug). Subcellular localization and possible function of actin, tropomyosin and actin-related protein 3 (Arp3) in the fission yeast Schizosaccharomyces pombe.
Balasubramanian MK, et al. (1998 Jul). Isolation and characterization of new fission yeast cytokinesis mutants.
Bähler J, et al. (1998 May 1). Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.
Demeter J, et al. (1998 Oct 19). imp2, a new component of the actin ring in the fission yeast Schizosaccharomyces pombe.
Le Goff X, et al. (1999 Aug). Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe.
Rupes I, et al. (1999 May). Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast.
McCollum D, et al. (1999 May 28). Identification of cold-sensitive mutations in the Schizosaccharomyces pombe actin locus.
Cullen CF, et al. (2000 Aug). A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast.
Motegi F, et al. (2000 May). Molecular mechanism of myosin-II assembly at the division site in Schizosaccharomyces pombe.
Trautmann S, et al. (2001 Jun 26). Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression.
Pelham RJ Jr, et al. (2001 Mar). Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe.
Nakano K, et al. (2001 Nov). Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton.
Kurahashi H, et al. (2002 Apr). Tropomyosin is required for the cell fusion process during conjugation in fission yeast.
Salus SS, et al. (2002 Dec). The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport.
Hou MC, et al. (2003 Jan 1). Mob2p interacts with the protein kinase Orb6p to promote coordination of cell polarity with cell cycle progression.
Wu JQ, et al. (2003 Nov). Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.
Pearson CL, et al. (2004 Aug). MesA, a novel fungal protein required for the stabilization of polarity axes in Aspergillus nidulans.
Deutschbauer AM, et al. (2005 Dec). Quantitative trait loci mapped to single-nucleotide resolution in yeast.
Kovar DR, et al. (2005 May). Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.
Nakano K, et al. (2006 Apr). Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast.
Skoumpla K, et al. (2007 May 1). Acetylation regulates tropomyosin function in the fission yeast Schizosaccharomyces pombe.
Savoldi M, et al. (2008 Oct). Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase.
Skau CT, et al. (2009 Apr). Role of tropomyosin in formin-mediated contractile ring assembly in fission yeast.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Sato I, et al. (2009 Mar 20). The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase.
Clayton JE, et al. (2010 Aug 24). Differential regulation of unconventional fission yeast myosins via the actin track.
Skau CT, et al. (2010 Aug 24). Fimbrin and tropomyosin competition regulates endocytosis and cytokinesis kinetics in fission yeast.
Stark BC, et al. (2010 Mar 15). Tropomyosin and myosin-II cellular levels promote actomyosin ring assembly in fission yeast.
Coulton AT, et al. (2010 Oct 1). The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Bitsikas V, et al. (2011 Jan). Hypertonic conditions trigger transient plasmolysis, growth arrest and blockage of transporter endocytosis in Aspergillus nidulans and Saccharomyces cerevisiae.
Skau CT, et al. (2011 Jul 29). Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.
East DA, et al. (2011 Sep 1). Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Cranz-Mileva S, et al. (2013). A molecular evolution approach to study the roles of tropomyosin in fission yeast.
Subramanian D, et al. (2013 Jun). Insight into actin organization and function in cytokinesis from analysis of fission yeast mutants.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Goss JW, et al. (2014 Jul 1). Characterization of the roles of Blt1p in fission yeast cytokinesis.
Johnson M, et al. (2014 Jul 7). Formins determine the functional properties of actin filaments in yeast.
Takaine M, et al. (2015 Aug 1). An actin-myosin-II interaction is involved in maintaining the contractile ring in fission yeast.
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Cranz-Mileva S, et al. (2015 Jul 17). Evolutionarily conserved sites in yeast tropomyosin function in cell polarity, transport and contractile ring formation.
Dudin O, et al. (2015 Mar 30). A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.
Brooker HR, et al. (2016 Sep). Analysis of biophysical and functional consequences of tropomyosin-fluorescent protein fusions.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04214
EOG82280W
sce:MAD1
Genes: 27
EOG82280W
sce:MAD1
Genes: 27
SGD Description
Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability
PomBase Description
mitotic spindle checkpoint protein Mad1
AspGD Description
Ortholog(s) have role in protein localization to kinetochore and condensed nuclear chromosome kinetochore, nuclear pore, nucleoplasm localization
References
Hardwick KG, et al. (1995 Nov). Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast.
Hardwick KG, et al. (1996 Aug 16). Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.
Chen RH, et al. (1999 Aug). The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins.
Brady DM, et al. (2000 Jun 1). Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function.
Fraschini R, et al. (2001 Dec 3). Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores.
Ikui AE, et al. (2002 Apr 15). Control of localization of a spindle checkpoint protein, Mad2, in fission yeast.
Lou Y, et al. (2004 May 7). NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.
Vanoosthuyse V, et al. (2004 Nov). Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p.
Minoda A, et al. (2005 Jan). BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere.
Asakawa K, et al. (2006 Mar). The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint.
Chung KS, et al. (2008 Aug). Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants.
Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
De Souza CP, et al. (2009 Apr). Mlp1 acts as a mitotic scaffold to spatially regulate spindle assembly checkpoint proteins in Aspergillus nidulans.
Choi SH, et al. (2009 Jun 23). Phosphorylation state defines discrete roles for monopolin in chromosome attachment and spindle elongation.
Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.
De Souza CP, et al. (2011 Jun 3). Regulated inactivation of the spindle assembly checkpoint without functional mitotic spindles.
Zich J, et al. (2012 Feb 21). Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.
Ito D, et al. (2012 Jan 3). Centromere-tethered Mps1 pombe homolog (Mph1) kinase is a sufficient marker for recruitment of the spindle checkpoint protein Bub1, but not Mad1.
Shepperd LA, et al. (2012 May 22). Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.
Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Hou H, et al. (2012 Nov 26). Csi1 links centromeres to the nuclear envelope for centromere clustering.
Heinrich S, et al. (2013 Nov). Determinants of robustness in spindle assembly checkpoint signalling.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Heinrich S, et al. (2014 Mar). Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores.
Markossian S, et al. (2015 Feb 15). Nup2 requires a highly divergent partner, NupA, to fulfill functions at nuclear pore complexes and the mitotic chromatin region.
Akera T, et al. (2015 Sep). Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore.
Chmielewska AE, et al. (2016). The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04215
EOG82280W
sce:absent
Genes: 7
EOG82280W
sce:absent
Genes: 7
AspGD Description
Ortholog of A. nidulans FGSC A4 : AN0803, A. fumigatus Af293 : Afu1g14620, A. oryzae RIB40 : AO090003001568, Aspergillus wentii : Aspwe1_0027658 and Aspergillus sydowii : Aspsy1_0139476
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG04216
EOG82280W
sce:absent
Genes: 1
EOG82280W
sce:absent
Genes: 1
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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