FOG04208
EOG8280NH
EOG8866W0

sce:ASK1

Genes: 23

SGD Description
Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress


PomBase Description
DASH complex subunit Ask1


AspGD Description
Has domain(s) with predicted role in attachment of spindle microtubules to kinetochore, mitotic spindle organization in nucleus and DASH complex, mitotic spindle localization


References

Li Y, et al. (2002 Jan 15). The mitotic spindle is required for loading of the DASH complex onto the kinetochore.

Cheeseman IM, et al. (2002 Oct 18). Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p.

Shang C, et al. (2003 Aug). Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p.

Li Y, et al. (2003 Mar-Apr). The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae.

Miranda JJ, et al. (2005 Feb). The yeast DASH complex forms closed rings on microtubules.

Westermann S, et al. (2005 Jan 21). Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.

Joglekar AP, et al. (2006 Jun). Molecular architecture of a kinetochore-microtubule attachment site.

Asbury CL, et al. (2006 Jun 27). The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement.

Westermann S, et al. (2006 Mar 23). The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%