FOG04179
EOG83J9S8

sce:DAD3

Genes: 15

SGD Description
Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis


PomBase Description
DASH complex subunit Dad3


AspGD Description
Has domain(s) with predicted role in attachment of spindle microtubules to kinetochore, mitotic spindle organization in nucleus and DASH complex, mitotic spindle localization


References

Cheeseman IM, et al. (2002 Oct 18). Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p.

Liu X, et al. (2005 Aug 17). Molecular analysis of kinetochore architecture in fission yeast.

Miranda JJ, et al. (2005 Feb). The yeast DASH complex forms closed rings on microtubules.

Westermann S, et al. (2005 Jan 21). Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.

Joglekar AP, et al. (2006 Jun). Molecular architecture of a kinetochore-microtubule attachment site.

Asbury CL, et al. (2006 Jun 27). The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement.

Westermann S, et al. (2006 Mar 23). The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends.

Hou H, et al. (2012 Nov 26). Csi1 links centromeres to the nuclear envelope for centromere clustering.

Tay Z, et al. (2013). Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Nguyen TT, et al. (2015 Feb 11). Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.

Hu L, et al. (2016 Aug). Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.

Nguyen TT, et al. (2016 Jan 21). Predicting chemotherapeutic drug combinations through gene network profiling.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%