FOG04121
EOG880GDF
EOG8ZKH7T
sce:PIR3;PIR1;HSP150
Genes: 44
EOG880GDF
EOG8ZKH7T
sce:PIR3;PIR1;HSP150
Genes: 44
SGD Description
O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication|O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication|O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
References
Russo P, et al. (1992 May 1). A heat shock gene from Saccharomyces cerevisiae encoding a secretory glycoprotein.
Russo P, et al. (1992 Sep 15). A heat shock gene from Saccharomyces cerevisiae encoding a secretory glycoprotein.
Singer-Krüger B, et al. (1993 Jul 5). Partial purification and characterization of early and late endosomes from yeast. Identification of four novel proteins.
Toh-e A, et al. (1993 May). Three yeast genes, PIR1, PIR2 and PIR3, containing internal tandem repeats, are related to each other, and PIR1 and PIR2 are required for tolerance to heat shock.
Yun DJ, et al. (1997 Jun 24). Stress proteins on the yeast cell surface determine resistance to osmotin, a plant antifungal protein.
Mrsă V, et al. (1997 Sep 30). Specific labelling of cell wall proteins by biotinylation. Identification of four covalently linked O-mannosylated proteins of Saccharomyces cerevisiae.
Pardo M, et al. (1999 Apr). Two-dimensional analysis of proteins secreted by Saccharomyces cerevisiae regenerating protoplasts: a novel approach to study the cell wall.
Jung US, et al. (1999 Dec). Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway.
Mrsa V, et al. (1999 Jul). Role of NaOH-extractable cell wall proteins Ccw5p, Ccw6p, Ccw7p and Ccw8p (members of the Pir protein family) in stability of the Saccharomyces cerevisiae cell wall.
Kapteyn JC, et al. (1999 Mar). The contribution of the O-glycosylated protein Pir2p/Hsp150 to the construction of the yeast cell wall in wild-type cells and beta 1,6-glucan-deficient mutants.
Kapteyn JC, et al. (2000 Feb). The cell wall architecture of Candida albicans wild-type cells and cell wall-defective mutants.
Kandasamy R, et al. (2000 May 15). Evidence for the presence of pir-like proteins in Candida albicans.
Pardo M, et al. (2000 Oct). A proteomic approach for the study of Saccharomyces cerevisiae cell wall biogenesis.
Doolin MT, et al. (2001 Apr). Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p.
Moukadiri I, et al. (2001 Mar 15). YJL159w does encode Pir2/Hsp150.
Brachat S, et al. (2003). Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.
Sohn K, et al. (2003 Jan). EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays.
Boorsma A, et al. (2004 Apr 15). Characterization of the transcriptional response to cell wall stress in Saccharomyces cerevisiae.
de Groot PW, et al. (2004 Aug). Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins.
Marinangeli P, et al. (2004 Jan). Minisatellites in Saccharomyces cerevisiae genes encoding cell wall proteins: a new way towards wine strain characterisation.
Lotz H, et al. (2004 Jun). RBR1, a novel pH-regulated cell wall gene of Candida albicans, is repressed by RIM101 and activated by NRG1.
Martínez AI, et al. (2004 Oct). Role of Pir1 in the construction of the Candida albicans cell wall.
Teparić R, et al. (2004 Oct). Increased mortality of Saccharomyces cerevisiae cell wall protein mutants.
Lan CY, et al. (2004 Sep). Regulatory networks affected by iron availability in Candida albicans.
Prill SK, et al. (2005 Jan). PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance.
Yin QY, et al. (2005 May 27). Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages.
Verstrepen KJ, et al. (2005 Sep). Intragenic tandem repeats generate functional variability.
Mulhern SM, et al. (2006 Dec). Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditions.
Enjalbert B, et al. (2006 Feb). Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.
Yin QY, et al. (2007 Sep). Mass spectrometric quantitation of covalently bound cell wall proteins in Saccharomyces cerevisiae.
Sosinska GJ, et al. (2008 Feb). Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions.
Kovács M, et al. (2008 Nov). Characterization of Ccw7p cell wall proteins and the encoding genes of Saccharomyces cerevisiae wine yeast strains: relevance for flor formation.
Côte P, et al. (2009 Jul). Transcriptional analysis of the Candida albicans cell cycle.
Sorgo AG, et al. (2010 Aug). Mass spectrometric analysis of the secretome of Candida albicans.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
||
FOG04122
EOG880GDF
sce:CIS3
Genes: 22
EOG880GDF
sce:CIS3
Genes: 22
SGD Description
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
References
Mrsă V, et al. (1997 Sep 30). Specific labelling of cell wall proteins by biotinylation. Identification of four covalently linked O-mannosylated proteins of Saccharomyces cerevisiae.
Cappellaro C, et al. (1998 Oct). New potential cell wall glucanases of Saccharomyces cerevisiae and their involvement in mating.
Moukadiri I, et al. (1999 Aug). Identification of two mannoproteins released from cell walls of a Saccharomyces cerevisiae mnn1 mnn9 double mutant by reducing agents.
Jung US, et al. (1999 Dec). Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway.
Mrsa V, et al. (1999 Jul). Role of NaOH-extractable cell wall proteins Ccw5p, Ccw6p, Ccw7p and Ccw8p (members of the Pir protein family) in stability of the Saccharomyces cerevisiae cell wall.
Castillo L, et al. (2003 Aug). Functional analysis of the cysteine residues and the repetitive sequence of Saccharomyces cerevisiae Pir4/Cis3: the repetitive sequence is needed for binding to the cell wall beta-1,3-glucan.
Ecker M, et al. (2003 Jun). O-mannosylation precedes and potentially controls the N-glycosylation of a yeast cell wall glycoprotein.
Boorsma A, et al. (2004 Apr 15). Characterization of the transcriptional response to cell wall stress in Saccharomyces cerevisiae.
Teparić R, et al. (2004 Oct). Increased mortality of Saccharomyces cerevisiae cell wall protein mutants.
Yin QY, et al. (2005 May 27). Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages.
Ecker M, et al. (2006 Apr 28). Pir proteins of Saccharomyces cerevisiae are attached to beta-1,3-glucan by a new protein-carbohydrate linkage.
Fernández-Arenas E, et al. (2007 Mar). Integrated proteomics and genomics strategies bring new insight into Candida albicans response upon macrophage interaction.
Yin QY, et al. (2007 Sep). Mass spectrometric quantitation of covalently bound cell wall proteins in Saccharomyces cerevisiae.
Kung LA, et al. (2009). Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Bahnan W, et al. (2012 Aug). Deletion of the Candida albicans PIR32 results in increased virulence, stress response, and upregulation of cell wall chitin deposition.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
||
FOG04123
EOG880GDF
sce:absent
Genes: 4
EOG880GDF
sce:absent
Genes: 4
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG04124
EOG880GDF
sce:PIR5
Genes: 5
EOG880GDF
sce:PIR5
Genes: 5
SGD Description
Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication
References
Brachat S, et al. (2003). Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.
Enyenihi AH, et al. (2003 Jan). Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae.
Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.
de Lichtenberg U, et al. (2005 Nov). New weakly expressed cell cycle-regulated genes in yeast.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
