FOG04104
EOG88W9M5
sce:SIP2;GAL83
Genes: 34
EOG88W9M5
sce:SIP2;GAL83
Genes: 34
SGD Description
One of three beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; SIP2 has a paralog, GAL83, that arose from the whole genome duplication|One of three possible beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain; GAL83 has a paralog, SIP2, that arose from the whole genome duplication
PomBase Description
AMP-activated protein kinase beta subunit Amk2
AspGD Description
Ortholog(s) have AMP-activated protein kinase activity, receptor signaling complex scaffold activity
References
Swanson MS, et al. (1990 Sep). SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus.
Erickson JR, et al. (1993 Nov). Genetic and molecular characterization of GAL83: its interaction and similarities with other genes involved in glucose repression in Saccharomyces cerevisiae.
Yang X, et al. (1994 Dec 15). A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex.
Kail M, et al. (1996 Jun 30). Lambda clone B22 contains a 7676 bp genomic fragment of Saccharomyces cerevisiae chromosome VII spanning the VAM7-SPM2 intergenic region and containing three novel transcribed open reading frames.
Jiang R, et al. (1997 Apr). The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex.
Schmidt MC, et al. (2000 Sep 15). beta-subunits of Snf1 kinase are required for kinase function and substrate definition.
Vincent O, et al. (2001 May 1). Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism.
Nath N, et al. (2002 Dec 27). Purification and characterization of Snf1 kinase complexes containing a defined Beta subunit composition.
Lin SS, et al. (2003 Apr 11). Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Amodeo GA, et al. (2007 Sep 27). Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1.
Choi ID, et al. (2008 Dec 12). Novel Ree1 regulates the expression of ENO1 via the Snf1 complex pathway in Saccharomyces cerevisiae.
Mayer FV, et al. (2011 Nov 2). ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04105
EOG88W9M5
sce:absent
Genes: 8
EOG88W9M5
sce:absent
Genes: 8
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04106
EOG88W9M5
sce:absent
Genes: 3
EOG88W9M5
sce:absent
Genes: 3
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04107
EOG88W9M5
sce:SIP1
Genes: 5
EOG88W9M5
sce:SIP1
Genes: 5
SGD Description
Alternate beta-subunit of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
References
Yang X, et al. (1992 Jul 31). A protein kinase substrate identified by the two-hybrid system.
Yang X, et al. (1994 Dec 15). A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex.
Mylin LM, et al. (1994 Jul). SIP1 is a catabolite repression-specific negative regulator of GAL gene expression.
Long RM, et al. (1995 Mar). Genetic and carbon source regulation of phosphorylation of Sip1p, a Snf1p-associated protein involved in carbon response in Saccharomyces cerevisiae.
Jiang R, et al. (1997 Apr). The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex.
Schmidt MC, et al. (2000 Sep 15). beta-subunits of Snf1 kinase are required for kinase function and substrate definition.
Vincent O, et al. (2001 May 1). Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism.
Nath N, et al. (2002 Dec 27). Purification and characterization of Snf1 kinase complexes containing a defined Beta subunit composition.
Hedbacker K, et al. (2004 Mar). Cyclic AMP-dependent protein kinase regulates the subcellular localization of Snf1-Sip1 protein kinase.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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