FOG04082
EOG8B2RC5

sce:LEU3

Genes: 34

SGD Description
Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation


AspGD Description
Ortholog(s) have sequence-specific DNA binding, transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding and transcriptional repressor activity, more


References

Bartnik E, et al. (1980). New leucine auxotrophs of Aspergillus nidulans.

Friden P, et al. (1987 Aug). LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes.

Zhou K, et al. (1987 Jul 10). Structure of yeast regulatory gene LEU3 and evidence that LEU3 itself is under general amino acid control.

Polotnianka R, et al. (2004 Nov). TamA interacts with LeuB, the homologue of Saccharomyces cerevisiae Leu3p, to regulate gdhA expression in Aspergillus nidulans.

Galagan JE, et al. (2005 Dec 22). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.

Piskacek S, et al. (2007 Jun). Nine-amino-acid transactivation domain: establishment and prediction utilities.

Downes DJ, et al. (2013 Dec). Regulation of the NADP-glutamate dehydrogenase gene gdhA in Aspergillus nidulans by the Zn(II)2Cys6 transcription factor LeuB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 27 genes with posterior transmembrane prediction > 50%

FOG04083
EOG8B2RC5

sce:SEF1

Genes: 26

SGD Description
Putative transcription factor; has homolog in Kluyveromyces lactis


References

Groom KR, et al. (1998 Jan 15). Kluyveromyces lactis SEF1 and its Saccharomyces cerevisiae homologue bypass the unknown essential function, but not the mitochondrial RNase P function, of the S. cerevisiae RPM2 gene.

Lan CY, et al. (2004 Sep). Regulatory networks affected by iron availability in Candida albicans.

Maicas S, et al. (2005). In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.

Homann OR, et al. (2009 Dec). A phenotypic profile of the Candida albicans regulatory network.

Linde J, et al. (2010 Nov 4). Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells.

Vandeputte P, et al. (2011). In vivo systematic analysis of Candida albicans Zn2-Cys6 transcription factors mutants for mice organ colonization.

Chen C, et al. (2011 Aug 18). An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.

Chen C, et al. (2012). Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 21 genes with posterior transmembrane prediction > 50%

FOG04084
EOG8B2RC5

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG04085
EOG8B2RC5

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted RNA polymerase II transcription factor activity, sequence-specific DNA binding, zinc ion binding activity, role in regulation of transcription, DNA-templated and nucleus localization|Has domain(s) with predicted DNA binding, zinc ion binding activity, role in transcription, DNA-templated and nucleus localization|Has domain(s) with predicted DNA binding, zinc ion binding activity, role in transcription, DNA-templated and nucleus localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%