FOG04060
EOG8C86BD

sce:CDC33

Genes: 38

SGD Description
mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth


PomBase Description
translation initiation factor eIF4E, 4F complex E subunit isoform 2, stress response factor|translation initiation factor eIF4E, 4F complex subunit


AspGD Description
Ortholog(s) have translation initiation factor activity, role in translational initiation and cytosol, nucleus localization


References

Altmann M, et al. (1987 Mar). mRNA cap-binding protein: cloning of the gene encoding protein synthesis initiation factor eIF-4E from Saccharomyces cerevisiae.

Brenner C, et al. (1988 Aug). CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae.

Altmann M, et al. (1989 Oct). Translation in Saccharomyces cerevisiae: initiation factor 4E-dependent cell-free system.

Zanchin NI, et al. (1995 Nov 3). Characterization of the in vivo phosphorylation sites of the mRNA.cap-binding complex proteins eukaryotic initiation factor-4E and p20 in Saccharomyces cerevisiae.

Matsuo H, et al. (1997 Sep). Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.

Daga RR, et al. (1999 Sep). Translational control of the cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growth.

Tharun S, et al. (2001 Nov). Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs.

Ptushkina M, et al. (2004 Mar). eIF4E isoform 2 in Schizosaccharomyces pombe is a novel stress-response factor.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Lee JH, et al. (2012). The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04061
EOG8C86BD

sce:absent

Genes: 12

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04062
EOG8C86BD

sce:absent

Genes: 9

AspGD Description
Has domain(s) with predicted translation initiation factor activity, role in translational initiation and cytoplasm localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04063
EOG8C86BD

sce:absent

Genes: 4

AspGD Description
Has domain(s) with predicted translation initiation factor activity, role in translational initiation and cytoplasm localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%