FOG04049
EOG8CVDP5

sce:NPR1

Genes: 32

SGD Description
Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex; NPR1 has a paralog, PRR2, that arose from the whole genome duplication


PomBase Description
serine/threonine protein kinase Oca2


References

Grenson M, et al. (1983 Jun 1). Study of the positive control of the general amino-acid permease and other ammonia-sensitive uptake systems by the product of the NPR1 gene in the yeast Saccharomyces cerevisiae.

Vandenbol M, et al. (1990 Jul). The Saccharomyces cerevisiae NPR1 gene required for the activity of ammonia-sensitive amino acid permeases encodes a protein kinase homologue.

Schmidt A, et al. (1998 Dec 1). The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.

Jacinto E, et al. (2001 Nov). TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.

De Craene JO, et al. (2001 Nov 23). The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease.

Crespo JL, et al. (2004 Sep 3). NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae.

Tate JJ, et al. (2006 Sep 22). Ammonia-specific regulation of Gln3 localization in Saccharomyces cerevisiae by protein kinase Npr1.

Feller A, et al. (2006 Sep 29). Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.

Boeckstaens M, et al. (2007 Apr). The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium.

Gander S, et al. (2008 Dec). Identification of the rapamycin-sensitive phosphorylation sites within the Ser/Thr-rich domain of the yeast Npr1 protein kinase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 11 genes with posterior transmembrane prediction > 50%

FOG04050
EOG8CVDP5

sce:HRK1.00

Genes: 25

SGD Description
Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress


References

Chéret G, et al. (1996 Sep). DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae.

Goossens A, et al. (2000 Oct). Regulation of yeast H(+)-ATPase by protein kinases belonging to a family dedicated to activation of plasma membrane transporters.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG04051
EOG8CVDP5

sce:RTK1

Genes: 24

SGD Description
Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress


AspGD Description
Ortholog(s) have protein serine/threonine kinase activity


References

Hunter T, et al. (1997 Jan). The protein kinases of budding yeast: six score and more.

Jelinsky SA, et al. (1999 Feb 16). Global response of Saccharomyces cerevisiae to an alkylating agent.

Breitkreutz A, et al. (2010 May 21). A global protein kinase and phosphatase interaction network in yeast.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 11 genes with posterior transmembrane prediction > 50%

FOG04052
EOG8CVDP5

sce:PRR2

Genes: 3

SGD Description
Serine/threonine protein kinase; inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance; PRR2 has a paralog, NPR1, that arose from the whole genome duplication


PomBase Description
serine/threonine protein kinase Ppk8 (predicted)


References

Zhu H, et al. (2000 Nov). Analysis of yeast protein kinases using protein chips.

Bertram PG, et al. (2000 Nov 17). Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases.

Burchett SA, et al. (2001 Jul 13). Identification of novel pheromone-response regulators through systematic overexpression of 120 protein kinases in yeast.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Ptacek J, et al. (2005 Dec 1). Global analysis of protein phosphorylation in yeast.

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Kaufmann I, et al. (2010 Jul). Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Tanae K, et al. (2012). Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Eckert D, et al. (2016 Jan). Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%