FOG04040
EOG8D51DR
sce:absent
Genes: 10
EOG8D51DR
sce:absent
Genes: 10
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04041
EOG8D51DR
sce:absent
Genes: 9
EOG8D51DR
sce:absent
Genes: 9
PomBase Description
autophagy associated protein kinase activator Atg17
AspGD Description
Scaffold protein of Atg1 signaling complex; not required for autophagy; mutant phenotype similar to wild-type growth on carbon and nitrogen limiting media, H2O2, menadione
References
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04042
EOG8D51DR
sce:ATG17
Genes: 5
EOG8D51DR
sce:ATG17
Genes: 5
SGD Description
Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells
References
Kamada Y, et al. (2000 Sep 18). Tor-mediated induction of autophagy via an Apg1 protein kinase complex.
Drees BL, et al. (2001 Aug 6). A protein interaction map for cell polarity development.
Wang Z, et al. (2001 Sep). Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p.
Nice DC, et al. (2002 Aug 16). Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy.
Klionsky DJ, et al. (2003 Oct). A unified nomenclature for yeast autophagy-related genes.
Yorimitsu T, et al. (2005 Apr). Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway.
Cheong H, et al. (2005 Jul). Atg17 regulates the magnitude of the autophagic response.
Kabeya Y, et al. (2005 May). Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy.
Kabeya Y, et al. (2007 May 4). Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae.
Ma J, et al. (2007 Nov-Dec). Overexpression of autophagy-related genes inhibits yeast filamentous growth.
Cheong H, et al. (2008 Feb). The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae.
Geng J, et al. (2008 Jul 14). Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy.
Bugnicourt A, et al. (2008 May). Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy.
Kawamata T, et al. (2008 May). Organization of the pre-autophagosomal structure responsible for autophagosome formation.
Krick R, et al. (2008 Oct). Piecemeal microautophagy of the nucleus requires the core macroautophagy genes.
Kageyama T, et al. (2009 Jan 16). Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae.
Yorimitsu T, et al. (2009 Jul). Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy.
Sekito T, et al. (2009 May). Atg17 recruits Atg9 to organize the pre-autophagosomal structure.
Kabeya Y, et al. (2009 Nov 27). Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
Stephan JS, et al. (2009 Oct 6). The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy.
Kamada Y, et al. (2010 Feb). Tor directly controls the Atg1 kinase complex to regulate autophagy.
Yen WL, et al. (2010 Jan 11). The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy.
Yeh YY, et al. (2010 Jul). Autophosphorylation within the Atg1 activation loop is required for both kinase activity and the induction of autophagy in Saccharomyces cerevisiae.
LeBlanc MA, et al. (2010 Oct 29). Lipid binding requirements for oxysterol-binding protein Kes1 inhibition of autophagy and endosome-trans-Golgi trafficking pathways.
Yeh YY, et al. (2011 Aug 19). An Atg13 protein-mediated self-association of the Atg1 protein kinase is important for the induction of autophagy.
Yamagata M, et al. (2011 Jul 15). Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae.
Mijaljica D, et al. (2012). A late form of nucleophagy in Saccharomyces cerevisiae.
Nakatogawa H, et al. (2012 Aug 17). The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation.
Ragusa MJ, et al. (2012 Dec 21). Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis.
Kraft C, et al. (2012 Sep 12). Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.
Dotiwala F, et al. (2013 Jan 2). DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase.
Fujioka Y, et al. (2014 Jun). Structural basis of starvation-induced assembly of the autophagy initiation complex.
Yamamoto H, et al. (2016 Jul 11). The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04043
EOG8D51DR
sce:SPO21
Genes: 1
EOG8D51DR
sce:SPO21
Genes: 1
SGD Description
Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog, YSW1, that arose from the whole genome duplication
References
Knop M, et al. (2000 Jul 17). Role of the spindle pole body of yeast in mediating assembly of the prospore membrane during meiosis.
Wesp A, et al. (2001 Apr). Conservative duplication of spindle poles during meiosis in Saccharomyces cerevisiae.
Bajgier BK, et al. (2001 Jun). SPO21 is required for meiosis-specific modification of the spindle pole body in yeast.
Nickas ME, et al. (2002 Apr). Ady3p links spindle pole body function to spore wall synthesis in Saccharomyces cerevisiae.
Nickas ME, et al. (2003 Jun). Ady4p and Spo74p are components of the meiotic spindle pole body that promote growth of the prospore membrane in Saccharomyces cerevisiae.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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