FOG04035
EOG8DBS0H

sce:MCM21

Genes: 20

SGD Description
Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; modified by sumoylation; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2


References

Poddar A, et al. (1999 Jan). MCM21 and MCM22, two novel genes of the yeast Saccharomyces cerevisiae are required for chromosome transmission.

Ortiz J, et al. (1999 May 1). A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore.

Cheeseman IM, et al. (2002 Oct 18). Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p.

De Wulf P, et al. (2003 Dec 1). Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes.

Schmitzberger F, et al. (2012 Mar 1). RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%