FOG04012
EOG8FXPPG

sce:NUT1

Genes: 28

SGD Description
Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription


AspGD Description
Has domain(s) with predicted RNA polymerase II transcription cofactor activity, role in regulation of transcription from RNA polymerase II promoter and mediator complex localization


References

Tabtiang RK, et al. (1998 Aug). Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae.

Gustafsson CM, et al. (1998 Nov 20). Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae.

Davis JA, et al. (2002 Aug). Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction.

Kuras L, et al. (2003 Nov 25). Association of the Mediator complex with enhancers of active genes.

Guglielmi B, et al. (2004). A high resolution protein interaction map of the yeast Mediator complex.

Bourbon HM, et al. (2004 Jun 4). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

van de Peppel J, et al. (2005 Aug 19). Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.

Nair D, et al. (2005 Oct 7). Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts.

Takagi Y, et al. (2005 Sep 2). Preponderance of free mediator in the yeast Saccharomyces cerevisiae.

Fan X, et al. (2006 Feb). Activator-specific recruitment of Mediator in vivo.

Takagi Y, et al. (2006 Jan 6). Mediator as a general transcription factor.

Baidoobonso SM, et al. (2007 Feb 23). Med19(Rox3) regulates Intermodule interactions in the Saccharomyces cerevisiae mediator complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 23 genes with posterior transmembrane prediction > 50%