FOG03991
EOG8GHX80

sce:NBP2

Genes: 33

SGD Description
Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)


PomBase Description
Shk1 kinase binding protein 5


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN3819, A. fumigatus Af293 : Afu2g03680, Aspergillus wentii : Aspwe1_0051534, Aspergillus sydowii : Aspsy1_0088765 and Aspergillus terreus NIH2624 : ATET_09522


References

Yang P, et al. (1999 Dec 17). Direct activation of the fission yeast PAK Shk1 by the novel SH3 domain protein, Skb5.

Ohkuni K, et al. (2003 Oct). Yeast Nap1-binding protein Nbp2p is required for mitotic growth at high temperatures and for cell wall integrity.

Mapes J, et al. (2004 Jan 28). Nbp2 targets the Ptc1-type 2C Ser/Thr phosphatase to the HOG MAPK pathway.

Du Y, et al. (2006 Oct 4). Ptc1p regulates cortical ER inheritance via Slt2p.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stanger K, et al. (2012 Jun 22). Yeast adaptor protein, Nbp2p, is conserved regulator of fungal Ptc1p phosphatases and is involved in multiple signaling pathways.

Deng L, et al. (2013 Jun). Compartmentalized nodes control mitotic entry signaling in fission yeast.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Kanda Y, et al. (2016 Aug 15). Skb5, an SH3 adaptor protein, regulates Pmk1 MAPK signaling by controlling the intracellular localization of the MAPKKK Mkh1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%