FOG03969
EOG8J9KFZ

sce:YAK1

Genes: 35

SGD Description
Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose


PomBase Description
serine/threonine protein kinase Ppk15 (predicted)


AspGD Description
Ortholog(s) have protein serine/threonine kinase activity, protein tyrosine kinase activity


References

Garrett S, et al. (1989 Sep). Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase.

Kassis S, et al. (2000 Jun 1). Saccharomyces cerevisiae Yak1p protein kinase autophosphorylates on tyrosine residues and phosphorylates myelin basic protein on a C-terminal serine residue.

Moriya H, et al. (2001 May 15). Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Bimbó A, et al. (2005 Apr). Systematic deletion analysis of fission yeast protein kinases.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.

Shiroiwa Y, et al. (2011 Mar 21). Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeast.

Courcet JB, et al. (2012 Dec). The DYRK1A gene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy.

Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 15 genes with posterior transmembrane prediction > 50%

FOG03970
EOG8J9KFZ

sce:KNS1

Genes: 34

SGD Description
Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation


PomBase Description
dual specificity protein kinase Lkh1


AspGD Description
Ortholog(s) have protein serine/threonine kinase activity


References

Padmanabha R, et al. (1991 Sep). The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family.

Lee K, et al. (1996 Nov 1). Activity and autophosphorylation of LAMMER protein kinases.

Kim KH, et al. (2001 Dec 21). Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER kinase homolog.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Kang EH, et al. (2013). LAMMER Kinase LkhA plays multiple roles in the vegetative growth and asexual and sexual development of Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG03971
EOG8J9KFZ

sce:absent

Genes: 29

PomBase Description
DYRK family protein kinase Pom1|DYRK family protein kinase Pom2


AspGD Description
Ortholog(s) have role in ascospore formation, hyphal growth, response to oxidative stress, sporocarp development involved in sexual reproduction

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG03972
EOG8J9KFZ

sce:absent

Genes: 11

PomBase Description
serine/threonine protein kinase Prp4


AspGD Description
Ortholog(s) have nucleus localization


References

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

De Souza CP, et al. (2014). Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%