FOG03941
EOG8M908Q

sce:IZH3

Genes: 33

SGD Description
Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity


PomBase Description
Haemolysin-III family protein (predicted)


AspGD Description
Ortholog(s) have Golgi apparatus, endoplasmic reticulum localization


References

Lyons TJ, et al. (2004 Apr 13). Metalloregulation of yeast membrane steroid receptor homologs.

Galagan JE, et al. (2005 Dec 22). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.

Lafon A, et al. (2006 Jul). G-protein and cAMP-mediated signaling in aspergilli: a genomic perspective.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG03942
EOG8M908Q

sce:IZH2

Genes: 29

SGD Description
Plasma membrane receptor for plant antifungal protein, osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to the IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; similar to mammalian adiponectins


PomBase Description
Haemolysin-III family plasma membrane receptor implicated in zinc ion homeostasis Izh2 (predicted)


AspGD Description
Ortholog(s) have role in cellular zinc ion homeostasis, negative regulation of transcription from RNA polymerase II promoter, response to toxic substance and plasma membrane localization


References

Karpichev IV, et al. (1998 Nov). Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae.

Karpichev IV, et al. (2002 May 31). Multiple regulatory roles of a novel Saccharomyces cerevisiae protein, encoded by YOL002c, in lipid and phosphate metabolism.

Lafon A, et al. (2006 Jul). G-protein and cAMP-mediated signaling in aspergilli: a genomic perspective.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%

FOG03943
EOG8M908Q

sce:IZH1

Genes: 6

SGD Description
Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication


References

Lyons TJ, et al. (2000 Jul 5). Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast.

Lyons TJ, et al. (2004 Apr 13). Metalloregulation of yeast membrane steroid receptor homologs.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG03944
EOG8M908Q

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted integral component of membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%