FOG03913
EOG8NCK15
EOG8XWDG5

sce:SRB6

Genes: 17

SGD Description
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation


PomBase Description
mediator complex subunit Med22


References

Thompson CM, et al. (1993 Jul 2). A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.

Kim YJ, et al. (1994 May 20). A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.

Lee TI, et al. (1998 Aug). Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme.

Koh SS, et al. (1998 May). An activator target in the RNA polymerase II holoenzyme.

Davis JA, et al. (2002 Aug). Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction.

Kuras L, et al. (2003 Nov 25). Association of the Mediator complex with enhancers of active genes.

Guglielmi B, et al. (2004). A high resolution protein interaction map of the yeast Mediator complex.

Bourbon HM, et al. (2004 Jun 4). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

Nair D, et al. (2005 Oct 7). Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts.

Takagi Y, et al. (2005 Sep 2). Preponderance of free mediator in the yeast Saccharomyces cerevisiae.

Takagi Y, et al. (2006 Aug 4). Head module control of mediator interactions.

Takagi Y, et al. (2006 Jan 6). Mediator as a general transcription factor.

Baidoobonso SM, et al. (2007 Feb 23). Med19(Rox3) regulates Intermodule interactions in the Saccharomyces cerevisiae mediator complex.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%