FOG03902
EOG8P2NMQ

sce:RTN1

Genes: 31

SGD Description
Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication


PomBase Description
reticulon-like protein Rtn1


AspGD Description
Protein of unknown function; expression repressed by tunicamycin and DTT


References

Godoy C, et al. (1996 Aug). Characterization of cwl1+, a gene from Schizosaccharomyces pombe whose overexpression causes cell lysis.

Oertle T, et al. (2003 Jul). A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Zhang D, et al. (2010 Jun 8). The cortical ER network limits the permissive zone for actomyosin ring assembly.

Chadrin A, et al. (2010 May 31). Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Zhang D, et al. (2012 Nov 6). Plasma membrane tethering of the cortical ER necessitates its finely reticulated architecture.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Zhang D, et al. (2014 Oct 1). Tts1, the fission yeast homologue of the TMEM33 family, functions in NE remodeling during mitosis.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%