FOG03866
EOG8PVMM7

sce:HSK3

Genes: 12

SGD Description
Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis


PomBase Description
DASH complex subunit Dad5


References

Aiba H, et al. (1998 Oct). Isolation and characterization of high-osmolarity-sensitive mutants of fission yeast.

Aoyama K, et al. (2000 May). Identification and characterization of a novel gene, hos3+, the function of which is necessary for growth under high osmotic stress in fission yeast.

Liu X, et al. (2005 Aug 17). Molecular analysis of kinetochore architecture in fission yeast.

Miranda JJ, et al. (2005 Feb). The yeast DASH complex forms closed rings on microtubules.

Li JM, et al. (2005 Jan). Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.

Westermann S, et al. (2005 Jan 21). Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.

Joglekar AP, et al. (2006 Jun). Molecular architecture of a kinetochore-microtubule attachment site.

Asbury CL, et al. (2006 Jun 27). The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement.

Westermann S, et al. (2006 Mar 23). The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Hou H, et al. (2012 Nov 26). Csi1 links centromeres to the nuclear envelope for centromere clustering.

Tay Z, et al. (2013). Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.

Vachon L, et al. (2013 Aug). Functional characterization of fission yeast transcription factors by overexpression analysis.

Nguyen TT, et al. (2015 Feb 11). Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.

Nguyen TT, et al. (2016 Jan 21). Predicting chemotherapeutic drug combinations through gene network profiling.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%