FOG03797
EOG8TX9BZ

sce:RLF2

Genes: 28

SGD Description
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription


PomBase Description
CAF assembly factor (CAF-1) complex large subunit Pcf1


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN8236, A. fumigatus Af293 : Afu5g03720, A. oryzae RIB40 : AO090102000582, Aspergillus wentii : Aspwe1_0043079 and Aspergillus sydowii : Aspsy1_0120776


References

Enomoto S, et al. (1997 Feb 1). RLF2, a subunit of yeast chromatin assembly factor-I, is required for telomeric chromatin function in vivo.

Kaufman PD, et al. (1997 Feb 1). Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I.

Meijsing SH, et al. (2001 Dec 1). The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Dohke K, et al. (2008 Oct). Fission yeast chromatin assembly factor 1 assists in the replication-coupled maintenance of heterochromatin.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Yamane K, et al. (2011 Jan 7). Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic loci.

Kunoh T, et al. (2014). Pcf1, a large subunit of CAF-1, required for maintenance of checkpoint kinase Cds1 activity.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Pietrobon V, et al. (2014 Oct). The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%