FOG03687
EOG837PX9
sce:CLB4;CLB3
Genes: 37
EOG837PX9
sce:CLB4;CLB3
Genes: 37
SGD Description
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; CLB4 has a paralog, CLB3, that arose from the whole genome duplication|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress; CLB3 has a paralog, CLB4, that arose from the whole genome duplication
PomBase Description
cyclin Cig1
AspGD Description
Has domain(s) with predicted protein kinase binding activity, role in regulation of cyclin-dependent protein serine/threonine kinase activity and nucleus localization
References
Surana U, et al. (1991 Apr 5). The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.
Bueno A, et al. (1991 Jul 12). A fission yeast B-type cyclin functioning early in the cell cycle.
Fitch I, et al. (1992 Jul). Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.
Richardson H, et al. (1992 Nov). Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.
Lopez-Girona A, et al. (1998 Jan). Negative regulation of Cdc18 DNA replication protein by Cdc2.
Snaith HA, et al. (1999 Jul). Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.
Blanco MA, et al. (2000 Aug 1). APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation.
Martín-Castellanos C, et al. (2000 Feb). The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size.
Tanaka K, et al. (2000 Sep). A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.
Decottignies A, et al. (2001 Jul). In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis.
Blanco MA, et al. (2001 Jun). Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation.
Bensen ES, et al. (2005 Jul). The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans.
Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.
Li CR, et al. (2008 Nov 19). The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Wu XZ, et al. (2010 Apr). Plagiochin E, an antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Gutiérrez-Escribano P, et al. (2015 Apr 20). A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Phobius transmembrane predictions
4 genes with posterior transmembrane prediction > 50% |
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FOG03688
EOG837PX9
sce:CLB2
Genes: 35
EOG837PX9
sce:CLB2
Genes: 35
SGD Description
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB2 has a paralog, CLB1, that arose from the whole genome duplication
PomBase Description
G2/M B-type cyclin Cdc13
AspGD Description
Ortholog(s) have cyclin-dependent protein serine/threonine kinase activator activity
References
Surana U, et al. (1991 Apr 5). The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.
Richardson H, et al. (1992 Nov). Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.
Kellogg DR, et al. (1995 Aug). Members of the NAP/SET family of proteins interact specifically with B-type cyclins.
Bensen ES, et al. (2005 Jul). The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans.
Li CR, et al. (2008 Nov 19). The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans.
McKenzie CG, et al. (2010 Apr). Contribution of Candida albicans cell wall components to recognition by and escape from murine macrophages.
Wu XZ, et al. (2010 Apr). Plagiochin E, an antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway.
Ofir A, et al. (2010 Sep). Candida albicans cyclin Clb4 carries S-phase cyclin activity.
Senn H, et al. (2012 Jan). Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
14 genes with posterior transmembrane prediction > 50% |
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FOG03689
EOG837PX9
sce:absent
Genes: 31
EOG837PX9
sce:absent
Genes: 31
PomBase Description
cyclin Puc1
AspGD Description
Ortholog(s) have role in hyphal growth
References
Forsburg SL, et al. (1991 May 16). Identification of a G1-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe.
Whiteway M, et al. (1992 Oct 15). Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.
Obara-Ishihara T, et al. (1994 Apr 15). A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.
Sherlock G, et al. (1994 Dec 15). Molecular cloning and analysis of CDC28 and cyclin homologues from the human fungal pathogen Candida albicans.
Forsburg SL, et al. (1994 Mar). Analysis of the Schizosaccharomyces pombe cyclin puc1: evidence for a role in cell cycle exit.
Loeb JD, et al. (1999 Jun). A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans.
Martín-Castellanos C, et al. (2000 Feb). The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size.
Tanaka K, et al. (2000 Sep). A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Bensen ES, et al. (2005 Jul). The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans.
Singh A, et al. (2007 Oct). cAMP regulates vegetative growth and cell cycle in Candida albicans.
Sinha I, et al. (2007 Sep). Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.
Wang A, et al. (2009 Aug). Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes.
Bishop A, et al. (2010 Sep 1). Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase.
Chauvel M, et al. (2012). A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness.
Gutiérrez-Escribano P, et al. (2015 Apr 20). A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.
Zhou H, et al. (2015 Oct). Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
10 genes with posterior transmembrane prediction > 50% |
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FOG03690
EOG837PX9
sce:CLB5
Genes: 7
EOG837PX9
sce:CLB5
Genes: 7
SGD Description
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication
References
Epstein CB, et al. (1992 Sep). CLB5: a novel B cyclin from budding yeast with a role in S phase.
Schwob E, et al. (1993 Jul). CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.
Kühne C, et al. (1993 Sep). A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG03691
EOG837PX9
sce:CLB1;CLB6
Genes: 5
EOG837PX9
sce:CLB1;CLB6
Genes: 5
SGD Description
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication|B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog, CLB5, that arose from the whole genome duplication
PomBase Description
G1/S-specific B-type cyclin Cig2|meiosis-specific cyclin Rem1
References
Ghiara JB, et al. (1991 Apr 5). A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis.
Surana U, et al. (1991 Apr 5). The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.
Schwob E, et al. (1993 Jul). CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.
Kühne C, et al. (1993 Sep). A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle.
Malapeira J, et al. (2005 Aug). A meiosis-specific cyclin regulated by splicing is required for proper progression through meiosis.
Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Gutiérrez-Escribano P, et al. (2015 Apr 20). A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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