FOG03677
EOG84J107

sce:SMC3

Genes: 32

SGD Description
Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member


PomBase Description
mitotic cohesin complex subunit Psm3


AspGD Description
Ortholog(s) have role in mitotic chromosome condensation, mitotic sister chromatid cohesion, positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric and cytosol, nuclear mitotic cohesin complex localization


References

Holt CL, et al. (1996 Mar). An extragenic suppressor of the mitosis-defective bimD6 mutation of Aspergillus nidulans codes for a chromosome scaffold protein.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Michaelis C, et al. (1997 Oct 3). Cohesins: chromosomal proteins that prevent premature separation of sister chromatids.

Anaya P, et al. (1998 May 12). Isolation of the Aspergillus nidulans sudD gene and its human homologue.

Tóth A, et al. (1999 Feb 1). Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.

Haering CH, et al. (2002 Apr). Molecular architecture of SMC proteins and the yeast cohesin complex.

Cheng J, et al. (2003 Jan). Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans.

Osmani SA, et al. (2004 Apr). The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Zhang J, et al. (2008 Jul 11). Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03678
EOG84J107

sce:SMC4

Genes: 32

SGD Description
Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate


PomBase Description
condensin complex SMC subunit Smc4


AspGD Description
Ortholog(s) have ATPase activity, role in mitotic chromosome condensation and cytosol, nuclear condensin complex localization


References

Freeman L, et al. (2000 May 15). The condensin complex governs chromosome condensation and mitotic transmission of rDNA.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03679
EOG84J107

sce:SMC1

Genes: 31

SGD Description
Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure


PomBase Description
mitotic cohesin complex subunit Psm1


AspGD Description
Ortholog(s) have role in mitotic sister chromatid cohesion and nuclear mitotic cohesin complex localization


References

Strunnikov AV, et al. (1993 Dec). SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.

Tóth A, et al. (1999 Feb 1). Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.

Tomonaga T, et al. (2000 Nov 1). Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase.

Haering CH, et al. (2002 Apr). Molecular architecture of SMC proteins and the yeast cohesin complex.

Sakai A, et al. (2003 Jun 2). Condensin but not cohesin SMC heterodimer induces DNA reannealing through protein-protein assembly.

Yuasa T, et al. (2004 Nov). An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Bernard P, et al. (2006 May 9). A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4.

Spirek M, et al. (2010 Feb). SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Murayama Y, et al. (2014 Jan 16). Biochemical reconstitution of topological DNA binding by the cohesin ring.

Murayama Y, et al. (2015 Dec 17). DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism.

Phadnis N, et al. (2015 May). Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.

Çamdere G, et al. (2015 Nov 19). The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering.

Birot A, et al. (2017 May 15). A second Wpl1 anti-cohesion pathway requires dephosphorylation of fission yeast kleisin Rad21 by PP4.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03680
EOG84J107

sce:SMC2

Genes: 25

SGD Description
Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus


PomBase Description
condensin complex SMC subunit Smc2


AspGD Description
Putative condensin-complex subunit


References

Strunnikov AV, et al. (1995 Mar 1). SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family.

Holt CL, et al. (1996 Mar). An extragenic suppressor of the mitosis-defective bimD6 mutation of Aspergillus nidulans codes for a chromosome scaffold protein.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Anaya P, et al. (1998 May 12). Isolation of the Aspergillus nidulans sudD gene and its human homologue.

Freeman L, et al. (2000 May 15). The condensin complex governs chromosome condensation and mitotic transmission of rDNA.

Cheng J, et al. (2003 Jan). Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans.

Osmani SA, et al. (2004 Apr). The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03681
EOG84J107

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%