FOG03587
EOG89W114
sce:FPR1
Genes: 35
EOG89W114
sce:FPR1
Genes: 35
SGD Description
Peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; N-terminally propionylated in vivo
PomBase Description
FKBP12 peptidyl-prolyl cis-trans isomerase Fkh1
AspGD Description
Peptidyl-prolyl isomerase|Ortholog(s) have role in TOR signaling
References
Siekierka JJ, et al. (1990 Dec 5). The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase.
Wiederrecht G, et al. (1991 Feb 1). FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.
Koltin Y, et al. (1991 Mar). Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.
Heitman J, et al. (1991 Mar 1). FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.
Rotonda J, et al. (1993 Apr 15). Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis.
Dolinski KJ, et al. (1999 Mar). Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
Kunz J, et al. (2000 Sep). FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.
Fitzgibbon GJ, et al. (2005 Sep). Genetic analysis of the TOR pathway in Aspergillus nidulans.
Pemberton TJ, et al. (2006 Sep 22). Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03588
EOG89W114
sce:FPR3
Genes: 34
EOG89W114
sce:FPR3
Genes: 34
SGD Description
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication
PomBase Description
FKBP-type peptidyl-prolyl cis-trans isomerase (predicted)
AspGD Description
Ortholog(s) have macrolide binding, peptidyl-prolyl cis-trans isomerase activity and role in histone peptidyl-prolyl isomerization, negative regulation of histone H3-K36 methylation, nucleosome assembly, regulation of growth rate
References
Shan X, et al. (1994 Aug). Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus.
Benton BM, et al. (1994 Nov). A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus.
Manning-Krieg UC, et al. (1994 Sep 19). Purification of FKBP-70, a novel immunophilin from Saccharomyces cerevisiae, and cloning of its structural gene, FPR3.
Wilson LK, et al. (1997 May 16). Casein kinase II catalyzes tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3.
Sydorskyy Y, et al. (2005 Jun 15). Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein.
Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.
Pemberton TJ, et al. (2006 Sep 22). Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.
Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03589
EOG89W114
sce:FPR2
Genes: 31
EOG89W114
sce:FPR2
Genes: 31
SGD Description
Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
AspGD Description
Putative peptidyl-prolyl isomerase; expression enhanced by maltose
References
Partaledis JA, et al. (1992 Aug). Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein.
Nielsen JB, et al. (1992 Aug 15). Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.
Pemberton TJ, et al. (2006 Sep 22). Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.
Herrero S, et al. (2011 May). The Aspergillus nidulans CENP-E kinesin motor KipA interacts with the fungal homologue of the centromere-associated protein CENP-H at the kinetochore.
Wartenberg D, et al. (2012 Jul 16). Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03590
EOG89W114
sce:absent
Genes: 31
EOG89W114
sce:absent
Genes: 31
SGD Description
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology
AspGD Description
Ortholog(s) have fungal-type vacuole membrane localization
References
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
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| Phobius transmembrane predictions
31 genes with posterior transmembrane prediction > 50% |
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FOG03591
EOG89W114
sce:FPR4
Genes: 1
EOG89W114
sce:FPR4
Genes: 1
SGD Description
Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR4 has a paralog, FPR3, that arose from the whole genome duplication
References
Dolinski K, et al. (1997 Nov 25). All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae.
Kuzuhara T, et al. (2004 Mar). A nuclear FK506-binding protein is a histone chaperone regulating rDNA silencing.
Sydorskyy Y, et al. (2005 Jun 15). Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein.
Xiao H, et al. (2006 Aug 7). The FK506-binding protein, Fpr4, is an acidic histone chaperone.
Nelson CJ, et al. (2006 Sep 8). Proline isomerization of histone H3 regulates lysine methylation and gene expression.
Monneau YR, et al. (2013 Sep 6). Structure and activity of the peptidyl-prolyl isomerase domain from the histone chaperone Fpr4 toward histone H3 proline isomerization.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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