FOG03536
EOG8JDFSX

sce:OPI1

Genes: 28

SGD Description
Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content, strongly correlated with overproduction of inositol


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN8817, A. fumigatus Af293 : Afu5g09420, A. oryzae RIB40 : AO090020000561, Aspergillus wentii : Aspwe1_0099437 and Aspergillus sydowii : Aspsy1_0159282


References

White MJ, et al. (1991 Jan 15). The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper.

Loewen CJ, et al. (2003 May 1). A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP.

Loewen CJ, et al. (2004 Jun 11). Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid.

Brickner JH, et al. (2004 Nov). Gene recruitment of the activated INO1 locus to the nuclear membrane.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%