FOG03513
EOG8Q2BWG

sce:HCS1

Genes: 34

SGD Description
Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities


PomBase Description
DNA polymerase alpha-associated DNA helicase A (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Biswas EE, et al. (1993 Dec 14). DNA helicase associated with DNA polymerase alpha: isolation by a modified immunoaffinity chromatography.

Biswas EE, et al. (1993 Mar 30). Characterization of the DNA-dependent ATPase and a DNA unwinding activity associated with the yeast DNA polymerase alpha complex.

Biswas EE, et al. (1993 Mar 30). Purification and characterization of a yeast DNA polymerase alpha complex with associated primase, 5'-->3' exonuclease, and DNA-dependent ATPase activities.

Biswas EE, et al. (1997 Oct 28). Yeast DNA helicase A: cloning, expression, purification, and enzymatic characterization.

Biswas SB, et al. (1997 Oct 28). Purification and characterization of DNA polymerase alpha-associated replication protein A-dependent yeast DNA helicase A.

Shiratori A, et al. (1999 Feb). Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03514
EOG8Q2BWG

sce:SEN1

Genes: 32

SGD Description
Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS


PomBase Description
ATP-dependent 5' to 3' DNA/RNA helicase Sen1|tRNA-splicing endonuclease positive effector Dbl8


AspGD Description
Ortholog(s) have mRNA binding, protein domain specific binding activity


References

DeMarini DJ, et al. (1992 May). SEN1, a positive effector of tRNA-splicing endonuclease in Saccharomyces cerevisiae.

Ursic D, et al. (1995 Dec 20). Inactivation of the yeast Sen1 protein affects the localization of nucleolar proteins.

Steinmetz EJ, et al. (1996 Dec). Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the putative helicase Sen1.

Ursic D, et al. (1997 Dec 1). The yeast SEN1 gene is required for the processing of diverse RNA classes.

Rasmussen TP, et al. (1998 Dec). The putative nucleic acid helicase Sen1p is required for formation and stability of termini and for maximal rates of synthesis and levels of accumulation of small nucleolar RNAs in Saccharomyces cerevisiae.

Steinmetz EJ, et al. (2001 Sep 20). RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts.

Ursic D, et al. (2004). Multiple protein/protein and protein/RNA interactions suggest roles for yeast DNA/RNA helicase Sen1p in transcription, transcription-coupled DNA repair and RNA processing.

Steinmetz EJ, et al. (2006 Dec 8). Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 8 genes with posterior transmembrane prediction > 50%

FOG03515
EOG8Q2BWG
EOG8T1G2B

sce:NAM7

Genes: 26

SGD Description
ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress


PomBase Description
ATP-dependent RNA helicase Upf1


AspGD Description
Ortholog(s) have role in circadian rhythm, hyphal growth, regulation of mRNA stability involved in response to oxidative stress and cytosol localization


References

Altamura N, et al. (1992 Apr 5). NAM7 nuclear gene encodes a novel member of a family of helicases with a Zn-ligand motif and is involved in mitochondrial functions in Saccharomyces cerevisiae.

Leeds P, et al. (1992 May). Gene products that promote mRNA turnover in Saccharomyces cerevisiae.

Cui Y, et al. (1996 Oct 15). Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency.

Sakamoto C, et al. (2004 Jan). Fission yeast epsin, Ent1p is required for endocytosis and involved in actin organization.

Rodríguez-Gabriel MA, et al. (2006 Sep). Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Viladevall L, et al. (2009 Mar 27). TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Wen J, et al. (2010 May 5). Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Zhang K, et al. (2011 Mar 25). Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Freitas JS, et al. (2011 Sep). Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH-sensing in the fungus Aspergillus nidulans.

Grenier St-Sauveur V, et al. (2013 Dec). Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.

Chen Q, et al. (2013 Jul 8). Actin filament severing by cofilin dismantles actin patches and produces mother filaments for new patches.

Matia-González AM, et al. (2013 Jun). Functional characterization of Upf1 targets in Schizosaccharomyces pombe.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Jongjitwimol J, et al. (2014). The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Duncan CD, et al. (2014 Jul). The translational landscape of fission-yeast meiosis and sporulation.

Hayashi T, et al. (2014 Jul). Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03516
EOG8Q2BWG

sce:ECM32

Genes: 18

SGD Description
DNA dependent ATPase/DNA helicase; helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes


References

Biswas EE, et al. (1995 Jan 26). Biochemical and genetic characterization of a replication protein A dependent DNA helicase from the yeast, Saccharomyces cerevisiae.

Lussier M, et al. (1997 Oct). Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae.

Kamimura YI, et al. (1999 Feb). DNA helicase III of Saccharomyces cerevisiae, encoded by YER176w (HEL1), highly unwinds covalently closed, circular DNA in the presence of a DNA topoisomerase and yRF-A.

Czaplinski K, et al. (2000 May). Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03517
EOG8Q2BWG

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%