FOG03269
EOG82281W

sce:SKN7

Genes: 32

SGD Description
Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog, HMS2, that arose from the whole genome duplication


PomBase Description
transcription factor Prr1


AspGD Description
Ortholog(s) have phosphorelay response regulator activity, sequence-specific DNA binding, transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding activity


References

Brown JL, et al. (1993 Nov). SKN7, a yeast multicopy suppressor of a mutation affecting cell wall beta-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors.

Brown JL, et al. (1994 Nov 1). Yeast Skn7p functions in a eukaryotic two-component regulatory pathway.

Krems B, et al. (1996 Mar). The response regulator-like protein Pos9/Skn7 of Saccharomyces cerevisiae is involved in oxidative stress resistance.

Li S, et al. (1998 Dec 1). The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p.

Raitt DC, et al. (2000 Jul). The Skn7 response regulator of Saccharomyces cerevisiae interacts with Hsf1 in vivo and is required for the induction of heat shock genes by oxidative stress.

Lu JM, et al. (2003 Dec). Saccharomyces cerevisiae histidine phosphotransferase Ypd1p shuttles between the nucleus and cytoplasm for SLN1-dependent phosphorylation of Ssk1p and Skn7p.

Singh P, et al. (2004 Apr). SKN7 of Candida albicans: mutant construction and phenotype analysis.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Hagiwara D, et al. (2007 Apr). The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans.

Asano Y, et al. (2007 Jul). Characterization of the bZip-type transcription factor NapA with reference to oxidative stress response in Aspergillus nidulans.

Hagiwara D, et al. (2007 Mar). Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses.

Azuma N, et al. (2007 Oct). In vitro analysis of His-Asp phosphorelays in Aspergillus nidulans: the first direct biochemical evidence for the existence of His-Asp phosphotransfer systems in filamentous fungi.

Vargas-Pérez I, et al. (2007 Sep). Response regulators SrrA and SskA are central components of a phosphorelay system involved in stress signal transduction and asexual sporulation in Aspergillus nidulans.

Hagiwara D, et al. (2009 Jul). Characterization of NikA histidine kinase and two response regulators with special reference to osmotic adaptation and asexual development in Aspergillus nidulans.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Hagiwara D, et al. (2009 Nov). Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress.

Colabardini AC, et al. (2010 Dec). Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.

Hagiwara D, et al. (2011 Apr). Characterization of the conserved phosphorylation site in the Aspergillus nidulans response regulator SrrA.

Lara-Rojas F, et al. (2011 Apr). Aspergillus nidulans transcription factor AtfA interacts with the MAPK SakA to regulate general stress responses, development and spore functions.

Eigentler A, et al. (2012 Jun). The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans.

Kovács Z, et al. (2013 May). Effect of cell wall integrity stress and RlmA transcription factor on asexual development and autolysis in Aspergillus nidulans.

Montibus M, et al. (2015). Coupling of transcriptional response to oxidative stress and secondary metabolism regulation in filamentous fungi.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03270
EOG82281W

sce:HSF1

Genes: 31

SGD Description
Trimeric heat shock transcription factor; activates multiple genes in response to highly diverse stresses, including hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; monitors translational status of cell at the ribosome through an RQC (Ribosomal Quality Control)-mediated translation-stress signal; involved in diauxic shift; posttranslationally regulated


PomBase Description
transcription factor Hsf1


References

Sorger PK, et al. (1988 Sep 9). Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation.

Wiederrecht G, et al. (1988 Sep 9). Isolation of the gene encoding the S. cerevisiae heat shock transcription factor.

Jakobsen BK, et al. (1991 Feb). A conserved heptapeptide restrains the activity of the yeast heat shock transcription factor.

Harrison CJ, et al. (1994 Jan 14). Crystal structure of the DNA binding domain of the heat shock transcription factor.

Kaiser B, et al. (1999 May). Identification of a gene encoding the pyruvate decarboxylase gene regulator CaPdc2p from Candida albicans.

Ramsdale M, et al. (2008 Oct). MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans.

Nicholls S, et al. (2009 Nov). Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals.

Nicholls S, et al. (2011 Mar). Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans.

Leach MD, et al. (2012). Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans.

Leach MD, et al. (2012 Dec). Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03271
EOG82281W

sce:SFL1

Genes: 29

SGD Description
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; premature stop codon (C1430T, Q477-stop) in SK1 background is linked to the aggressively invasive phenotype of SK1 relative to BY4741 (S288C)


AspGD Description
Ortholog(s) have role in conidium formation, response to heat


References

Fujita A, et al. (1989 Dec 28). Domains of the SFL1 protein of yeasts are homologous to Myc oncoproteins or yeast heat-shock transcription factor.

Li Y, et al. (2007 Nov). Roles of Candida albicans Sfl1 in hyphal development.

Bauer J, et al. (2007 Oct). Candida albicans Sfl1 suppresses flocculation and filamentation.

Hall RA, et al. (2011 Aug). The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans.

Song W, et al. (2011 Mar). Candida albicans Sfl2, a temperature-induced transcriptional regulator, is required for virulence in a murine gastrointestinal infection model.

Chauvel M, et al. (2012). A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness.

Znaidi S, et al. (2013 Aug). A comprehensive functional portrait of two heat shock factor-type transcriptional regulators involved in Candida albicans morphogenesis and virulence.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03272
EOG82281W

sce:MGA1

Genes: 4

SGD Description
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants


References

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03273
EOG82281W

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding activity, role in regulation of transcription, DNA-templated and nucleus localization


References

Colabardini AC, et al. (2010 Dec). Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03274
EOG82281W

sce:absent

Genes: 3

References

Spiering MJ, et al. (2010 Feb). Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted epithelial infection model.

Song W, et al. (2011 Mar). Candida albicans Sfl2, a temperature-induced transcriptional regulator, is required for virulence in a murine gastrointestinal infection model.

Chauvel M, et al. (2012). A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness.

Znaidi S, et al. (2013 Aug). A comprehensive functional portrait of two heat shock factor-type transcriptional regulators involved in Candida albicans morphogenesis and virulence.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03275
EOG82281W

sce:absent

Genes: 5

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%