FOG03170
EOG8RXWG5
EOG8ZCRRB

sce:EDC3

Genes: 31

SGD Description
Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress


PomBase Description
enhancer of mRNA decapping Edc3


AspGD Description
Ortholog(s) have mRNA binding activity


References

Kshirsagar M, et al. (2004 Feb). Identification of Edc3p as an enhancer of mRNA decapping in Saccharomyces cerevisiae.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Ling SH, et al. (2008 Oct). Crystal structure of human Edc3 and its functional implications.

Morozov IY, et al. (2010 Apr). Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans.

Fromm SA, et al. (2012 Jan 18). The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.

Wang CY, et al. (2013 Mar). Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Fromm SA, et al. (2014 Jul 7). In vitro reconstitution of a cellular phase-transition process that involves the mRNA decapping machinery.

Charenton C, et al. (2016 Nov). Structure of the active form of Dcp1-Dcp2 decapping enzyme bound to m⁷GDP and its Edc3 activator.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Wang CY, et al. (2017 Apr). Involvement of fission yeast Pdc2 in RNA degradation and P-body function.

Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG03171
EOG8G1K2P
EOG8ZCRRB

sce:CWC27

Genes: 24

SGD Description
Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress


PomBase Description
cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp7 (predicted)


AspGD Description
Has domain(s) with predicted peptidyl-prolyl cis-trans isomerase activity and role in protein folding, protein peptidyl-prolyl isomerization


References

Ohi MD, et al. (2002 Apr). Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.

Pemberton TJ, et al. (2006 Sep 22). Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03172
EOG8ZCRRB

sce:absent

Genes: 17

PomBase Description
WD repeat containing cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp9 (predicted)


AspGD Description
Ortholog(s) have nucleus localization


References

Pemberton TJ, et al. (2006 Sep 22). Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.

Li H, et al. (2007 Aug). A WD40 domain cyclophilin interacts with histone H3 and functions in gene repression and organogenesis in Arabidopsis.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Ucisik-Akkaya E, et al. (2014 Apr 11). A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Burr R, et al. (2016 Jun 3). Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03173
EOG8R4XM4
EOG8ZCRRB

sce:HSP42

Genes: 12

SGD Description
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress


References

Wotton D, et al. (1996 Feb 2). Multimerization of Hsp42p, a novel heat shock protein of Saccharomyces cerevisiae, is dependent on a conserved carboxyl-terminal sequence.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03174
EOG8ZCRRB

sce:absent

Genes: 10

AspGD Description
Has domain(s) with predicted peptidyl-prolyl cis-trans isomerase activity and role in protein folding, protein peptidyl-prolyl isomerization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03175
EOG8ZCRRB

sce:absent

Genes: 10

PomBase Description
cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp8


AspGD Description
Ortholog(s) have nucleus localization


References

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Pemberton TJ, et al. (2006 Sep 22). Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Kabeche R, et al. (2011 Nov). The filament-forming protein Pil1 assembles linear eisosomes in fission yeast.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Kallgren SP, et al. (2014). The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03176
EOG8ZCRRB

sce:absent

Genes: 8

PomBase Description
cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp1


AspGD Description
Ortholog(s) have peptidyl-prolyl cis-trans isomerase activity and cytosol, nucleus localization


References

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Pemberton TJ, et al. (2006 Sep 22). Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.

Fukumoto Y, et al. (2008 Nov). Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Kabeche R, et al. (2011 Nov). The filament-forming protein Pil1 assembles linear eisosomes in fission yeast.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Moreira KE, et al. (2012 Aug 6). Seg1 controls eisosome assembly and shape.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lacy MM, et al. (2017 Aug 15). Single-molecule imaging of the BAR-domain protein Pil1p reveals filament-end dynamics.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03177
EOG8R4XM4

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%