FOG03007
EOG82FR31
sce:FRQ1
Genes: 34
EOG82FR31
sce:FRQ1
Genes: 34
SGD Description
N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
PomBase Description
neuronal calcium sensor related protein Ncs1
AspGD Description
Ortholog(s) have 1-phosphatidylinositol 4-kinase activator activity, calcium ion binding activity
References
Hendricks KB, et al. (1999 Aug). Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase.
Ames JB, et al. (2000 Oct 10). Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae.
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0 genes with posterior transmembrane prediction > 50% |
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FOG03008
EOG82FR31
sce:CMD1
Genes: 33
EOG82FR31
sce:CMD1
Genes: 33
SGD Description
Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
PomBase Description
calmodulin Cam1
AspGD Description
Calmodulin
References
Davis TN, et al. (1986 Nov 7). Isolation of the yeast calmodulin gene: calmodulin is an essential protein.
Davis TN, et al. (1987). Isolation of the yeast calmodulin gene using synthetic oligonucleotide probes.
Bartelt DC, et al. (1988 May). Calmodulin-dependent multifunctional protein kinase in Aspergillus nidulans.
Rasmussen CD, et al. (1990 Aug 15). Characterization and expression of the unique calmodulin gene of Aspergillus nidulans.
Means AR, et al. (1991). Regulatory functions of calmodulin.
Geiser JR, et al. (1991 Jun 14). Can calmodulin function without binding calcium?
Lloyd AT, et al. (1991 Nov). Codon usage in Aspergillus nidulans.
Rasmussen CD, et al. (1992). Calmodulin and cell cycle control.
Brockerhoff SE, et al. (1992 Apr). Structural analysis of wild-type and mutant yeast calmodulins by limited proteolysis and electrospray ionization mass spectrometry.
Lu KP, et al. (1992 Mar). Cooperative regulation of cell proliferation by calcium and calmodulin in Aspergillus nidulans.
Geiser JR, et al. (1993 Dec). The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiae.
Lu KP, et al. (1993 May). Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans.
Lukas TJ, et al. (1994 Sep 29). Gain of function mutations for yeast calmodulin and calcium dependent regulation of protein kinase activity.
Nanthakumar NN, et al. (1996). Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.
Ohki S, et al. (1996 Jun). Secondary structure and Ca(2+)-binding property of the N-terminal half domain of calmodulin from yeast Saccharomyces cerevisiae as studied by NMR.
el-Rady J, et al. (1996 Jun-Jul). Isolation and characterization of a calmodulin-encoding cDNA from the pathogenic fungus Histoplasma capsulatum.
Dayton JS, et al. (1996 Oct). Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.
Rayner TF, et al. (1998 Jun 30). Identification and characterization of the KlCMD1 gene encoding Kluyveromyces lactis calmodulin.
Osherov N, et al. (1998 Oct 9). Structural requirements for in vivo myosin I function in Aspergillus nidulans.
Elliott S, et al. (1999 May 25). Spc29p is a component of the Spc110p subcomplex and is essential for spindle pole body duplication.
Joseph JD, et al. (2000 Dec 8). Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.
Joseph JD, et al. (2002 Feb). Calcium binding is required for calmodulin function in Aspergillus nidulans.
Wang G, et al. (2006 Sep). Calmodulin concentrates at the apex of growing hyphae and localizes to the Spitzenkörper in Aspergillus nidulans.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Chen S, et al. (2010 Mar). Localization and function of calmodulin in live-cells of Aspergillus nidulans.
Gerke J, et al. (2012 Jun). Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans.
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0 genes with posterior transmembrane prediction > 50% |
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FOG03009
EOG82FR31
sce:CDC31
Genes: 33
EOG82FR31
sce:CDC31
Genes: 33
SGD Description
Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
PomBase Description
centrin
AspGD Description
Ortholog(s) have structural constituent of cytoskeleton activity
References
Baum P, et al. (1986 Aug). Yeast gene required for spindle pole body duplication: homology of its product with Ca2+-binding proteins.
Vallen EA, et al. (1994 Jun). Genetic interactions between CDC31 and KAR1, two genes required for duplication of the microtubule organizing center in Saccharomyces cerevisiae.
Biggins S, et al. (1994 May). Direct interaction between yeast spindle pole body components: Kar1p is required for Cdc31p localization to the spindle pole body.
Spang A, et al. (1995 Mar). The Cdc31p-binding protein Kar1p is a component of the half bridge of the yeast spindle pole body.
Middendorp S, et al. (1997 Aug 19). Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene.
Sullivan DS, et al. (1998 Nov 2). The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity.
Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.
Ivanovska I, et al. (2001 Feb). Fine structure analysis of the yeast centrin, Cdc31p, identifies residues specific for cell morphology and spindle pole body duplication.
Jaspersen SL, et al. (2002 Dec 23). Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p.
Helfant AH, et al. (2002 Feb). Composition of the spindle pole body of Saccharomyces cerevisiae and the proteins involved in its duplication.
Paoletti A, et al. (2003 Jul). Fission yeast cdc31p is a component of the half-bridge and controls SPB duplication.
Suntharalingam M, et al. (2003 Jun). Peering through the pore: nuclear pore complex structure, assembly, and function.
Kilmartin JV, et al. (2003 Sep 29). Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication.
Osmani AH, et al. (2006). Identification and analysis of essential Aspergillus nidulans genes using the heterokaryon rescue technique.
Osmani AH, et al. (2006 Dec). Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Tamm T, et al. (2011 Oct 31). Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.
Johnson AE, et al. (2013 Oct 7). CK1 is required for a mitotic checkpoint that delays cytokinesis.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Myers MD, et al. (2017 Feb). Vps13 and Cdc31/centrin: Puzzling partners in membrane traffic.
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0 genes with posterior transmembrane prediction > 50% |
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FOG03010
EOG82FR31
sce:MLC1
Genes: 32
EOG82FR31
sce:MLC1
Genes: 32
SGD Description
Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
PomBase Description
myosin II light chain
AspGD Description
Ortholog(s) have calcium ion binding activity and role in mitotic actomyosin contractile ring assembly actin filament organization, protein localization to medial cortex, regulation of cell cycle, spore germination
References
Bartelt DC, et al. (1988 May). Calmodulin-dependent multifunctional protein kinase in Aspergillus nidulans.
Rasmussen CD, et al. (1990 Aug 15). Characterization and expression of the unique calmodulin gene of Aspergillus nidulans.
Means AR, et al. (1991). Regulatory functions of calmodulin.
Lloyd AT, et al. (1991 Nov). Codon usage in Aspergillus nidulans.
Rasmussen CD, et al. (1992). Calmodulin and cell cycle control.
Lu KP, et al. (1992 Mar). Cooperative regulation of cell proliferation by calcium and calmodulin in Aspergillus nidulans.
Lu KP, et al. (1993 May). Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans.
Nanthakumar NN, et al. (1996). Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.
el-Rady J, et al. (1996 Jun-Jul). Isolation and characterization of a calmodulin-encoding cDNA from the pathogenic fungus Histoplasma capsulatum.
Dayton JS, et al. (1996 Oct). Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.
Stevens RC, et al. (1998 Aug 10). Mlc1p is a light chain for the unconventional myosin Myo2p in Saccharomyces cerevisiae.
Osherov N, et al. (1998 Oct 9). Structural requirements for in vivo myosin I function in Aspergillus nidulans.
Boyne JR, et al. (2000 Dec). Yeast myosin light chain, Mlc1p, interacts with both IQGAP and class II myosin to effect cytokinesis.
Joseph JD, et al. (2000 Dec 8). Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.
Shannon KB, et al. (2000 Jun 15). A myosin light chain mediates the localization of the budding yeast IQGAP-like protein during contractile ring formation.
Wagner W, et al. (2002 Dec 2). Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p.
Joseph JD, et al. (2002 Feb). Calcium binding is required for calmodulin function in Aspergillus nidulans.
Terrak M, et al. (2002 Oct). Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V.
Terrak M, et al. (2003 Feb 3). Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications.
Luo J, et al. (2004 Jun 21). Identification and functional analysis of the essential and regulatory light chains of the only type II myosin Myo1p in Saccharomyces cerevisiae.
Wang G, et al. (2006 Sep). Calmodulin concentrates at the apex of growing hyphae and localizes to the Spitzenkörper in Aspergillus nidulans.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Chen S, et al. (2010 Mar). Localization and function of calmodulin in live-cells of Aspergillus nidulans.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Gerke J, et al. (2012 Jun). Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03011
EOG82FR31
sce:CNB1
Genes: 32
EOG82FR31
sce:CNB1
Genes: 32
SGD Description
Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress
PomBase Description
calcineurin regulatory subunit (calcineurin B)
AspGD Description
Ortholog(s) have calcium-dependent protein serine/threonine phosphatase activity, calcium-dependent protein serine/threonine phosphatase regulator activity
References
Kuno T, et al. (1991 Oct 31). cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae.
Cyert MS, et al. (1992 Aug). Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.
Chéret G, et al. (1993 Jun). DNA sequence analysis of the YCN2 region of chromosome XI in Saccharomyces cerevisiae.
Fujioka T, et al. (2007 Aug). MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Almeida RS, et al. (2013 Jul 8). Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis.
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1 genes with posterior transmembrane prediction > 50% |
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FOG03012
EOG82FR31
sce:absent
Genes: 6
EOG82FR31
sce:absent
Genes: 6
PomBase Description
myosin II regulatory light chain Rlc1
References
Le Goff X, et al. (2000 Dec). The S. pombe rlc1 gene encodes a putative myosin regulatory light chain that binds the type II myosins myo3p and myo2p.
Naqvi NI, et al. (2000 Nov). Type II myosin regulatory light chain relieves auto-inhibition of myosin-heavy-chain function.
Wu JQ, et al. (2003 Nov). Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.
Lord M, et al. (2004 Oct 25). UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.
Kovar DR, et al. (2005 May). Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.
Wu JQ, et al. (2005 Oct 14). Counting cytokinesis proteins globally and locally in fission yeast.
Chikashige Y, et al. (2006 Apr 7). Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
Martín-García R, et al. (2006 Jul 1). The fission yeast Chs2 protein interacts with the type-II myosin Myo3p and is required for the integrity of the actomyosin ring.
Pinar M, et al. (2008 Apr). Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.
Loo TH, et al. (2008 Dec 1). Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis.
Roberts-Galbraith RH, et al. (2009 Jan 12). The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
Sladewski TE, et al. (2009 Sep). Regulation of fission yeast myosin-II function and contractile ring dynamics by regulatory light-chain and heavy-chain phosphorylation.
Stark BC, et al. (2010 Mar 15). Tropomyosin and myosin-II cellular levels promote actomyosin ring assembly in fission yeast.
Padmanabhan A, et al. (2011 Mar 22). IQGAP-related Rng2p organizes cortical nodes and ensures position of cell division in fission yeast.
Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.
Bohnert KA, et al. (2013 Oct 1). SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.
Coffman VC, et al. (2013 Oct 14). The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Wang N, et al. (2014 May 12). The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis.
Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.
McDonald NA, et al. (2017 Sep 15). Nanoscale architecture of the <i>Schizosaccharomyces pombe</i> contractile ring.
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1 genes with posterior transmembrane prediction > 50% |
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FOG03013
EOG82FR31
sce:absent
Genes: 5
EOG82FR31
sce:absent
Genes: 5
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0 genes with posterior transmembrane prediction > 50% |
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FOG03014
EOG82FR31
sce:absent
Genes: 4
EOG82FR31
sce:absent
Genes: 4
AspGD Description
Has domain(s) with predicted calcium ion binding activity
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03015
EOG82FR31
sce:MLC2
Genes: 4
EOG82FR31
sce:MLC2
Genes: 4
SGD Description
Regulatory light chain for the type II myosin Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring
References
Luo J, et al. (2004 Jun 21). Identification and functional analysis of the essential and regulatory light chains of the only type II myosin Myo1p in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03016
EOG82FR31
sce:absent
Genes: 3
EOG82FR31
sce:absent
Genes: 3
AspGD Description
Has domain(s) with predicted calcium ion binding activity
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03017
EOG82FR31
sce:absent
Genes: 3
EOG82FR31
sce:absent
Genes: 3
PomBase Description
myosin I light chain Cam2
References
Lord M, et al. (2004 Oct 25). UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.
Itadani A, et al. (2006). Localization of type I myosin and F-actin to the leading edge region of the forespore membrane in Schizosaccharomyces pombe.
Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Sammons MR, et al. (2011 Jul 15). A calmodulin-related light chain from fission yeast that functions with myosin-I and PI 4-kinase.
Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Dudin O, et al. (2015 Mar 30). A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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