FOG02856
EOG8TQJRS

sce:SNF2

Genes: 34

SGD Description
Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p


PomBase Description
ATP-dependent DNA helicase Snf21|ATP-dependent DNA helicase Snf22


AspGD Description
Ortholog(s) have role in cellular response to biotic stimulus, cellular response to neutral pH and filamentous growth of a population of unicellular organisms in response to biotic stimulus, more


References

Laurent BC, et al. (1991 Apr 1). Functional interdependence of the yeast SNF2, SNF5, and SNF6 proteins in transcriptional activation.

Yoshimoto H, et al. (1991 Aug). The GAM1/SNF2 gene of Saccharomyces cerevisiae encodes a highly charged nuclear protein required for transcription of the STA1 gene.

Kodaki T, et al. (1995 Feb). The SNF2/SWI2/GAM1/TYE3/RIC1 gene is involved in the coordinate regulation of phospholipid synthesis in Saccharomyces cerevisiae.

Richmond E, et al. (1996 Oct 1). Functional analysis of the DNA-stimulated ATPase domain of yeast SWI2/SNF2.

Chéret G, et al. (1996 Sep). DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae.

Smith CL, et al. (2003 Feb). Structural analysis of the yeast SWI/SNF chromatin remodeling complex.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02857
EOG8TQJRS

sce:ISW1;ISW2

Genes: 56

SGD Description
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK|ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; the Isw2 complex exhibits basal levels of chromatin binding throughout the genome as well as target-specific chromatin interactions; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide


AspGD Description
Ortholog(s) have DNA translocase activity, chromatin binding, single-stranded DNA binding activity


References

Tsukiyama T, et al. (1999 Mar 15). Characterization of the imitation switch subfamily of ATP-dependent chromatin-remodeling factors in Saccharomyces cerevisiae.

Goldmark JP, et al. (2000 Oct 27). The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p.

Gelbart ME, et al. (2001 Mar). Interactions of Isw2 chromatin remodeling complex with nucleosomal arrays: analyses using recombinant yeast histones and immobilized templates.

Kent NA, et al. (2001 Mar 1). In vivo chromatin remodeling by yeast ISWI homologs Isw1p and Isw2p.

Fazzio TG, et al. (2001 Oct). Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression.

Sugiyama M, et al. (2001 Sep). The Saccharomyces cerevisiae Isw2p-Itc1p complex represses INO1 expression and maintains cell morphology.

Nobile CJ, et al. (2003 Dec). Genetic control of chlamydospore formation in Candida albicans.

Vary JC Jr, et al. (2003 Jan). Yeast Isw1p forms two separable complexes in vivo.

Morillon A, et al. (2003 Nov 14). Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II.

McConnell AD, et al. (2004 Apr). Histone fold protein Dls1p is required for Isw2-dependent chromatin remodeling in vivo.

Iida T, et al. (2004 Jan). Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae.

Enjalbert B, et al. (2006 Feb). Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.

Singh RP, et al. (2011 Jul 15). Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02858
EOG8TQJRS

sce:CHD1

Genes: 35

SGD Description
Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes


PomBase Description
ATP-dependent DNA helicase Hrp1|ATP-dependent DNA helicase Hrp3


AspGD Description
Ortholog(s) have ATP-dependent DNA helicase activity


References

Grant PA, et al. (1999 Feb 26). Expanded lysine acetylation specificity of Gcn5 in native complexes.

Tran HG, et al. (2000 May 15). The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor.

Pray-Grant MG, et al. (2002 Dec). The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.

Krogan NJ, et al. (2002 Oct). RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.

Simic R, et al. (2003 Apr 15). Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Robinson KM, et al. (2003 Nov). Replication-independent assembly of nucleosome arrays in a novel yeast chromatin reconstitution system involves antisilencing factor Asf1p and chromodomain protein Chd1p.

Wu PY, et al. (2004 Jul 23). Molecular architecture of the S. cerevisiae SAGA complex.

Pray-Grant MG, et al. (2005 Jan 27). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.

Stockdale C, et al. (2006 Jun 16). Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes.

Xella B, et al. (2006 Mar). The ISWI and CHD1 chromatin remodelling activities influence ADH2 expression and chromatin organization.

Jones HS, et al. (2007 Feb). RNA polymerase I in yeast transcribes dynamic nucleosomal rDNA.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Okuda M, et al. (2007 Jan 26). Structural polymorphism of chromodomains in Chd1.

Flanagan JF, et al. (2007 Jun 1). Molecular implications of evolutionary differences in CHD double chromodomains.

Ferreira H, et al. (2007 Nov 30). Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms.

Biswas D, et al. (2007 Sep). Chd1 and yFACT act in opposition in regulating transcription.

Warner MH, et al. (2007 Sep). Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification.

Biswas D, et al. (2008 Feb). A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02859
EOG8TQJRS

sce:IRC5

Genes: 32

SGD Description
Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci


AspGD Description
Ortholog(s) have role in mitotic recombination


References

Brachat S, et al. (2003). Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Alvaro D, et al. (2007 Dec). Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02860
EOG8TQJRS

sce:INO80

Genes: 34

SGD Description
ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription


PomBase Description
SNF2 family ATP-dependent 3' to 5' DNA helicase Ino80


AspGD Description
Ortholog(s) have role in chromatin remodeling and Ino80 complex localization


References

Shiratori A, et al. (1999 Feb). Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis.

Ebbert R, et al. (1999 May). The product of the SNF2/SWI2 paralogue INO80 of Saccharomyces cerevisiae required for efficient expression of various yeast structural genes is part of a high-molecular-weight protein complex.

Shen X, et al. (2000 Aug 3). A chromatin remodelling complex involved in transcription and DNA processing.

Steger DJ, et al. (2003 Jan 3). Regulation of chromatin remodeling by inositol polyphosphates.

Shen X, et al. (2003 Jul). Involvement of actin-related proteins in ATP-dependent chromatin remodeling.

Morrison AJ, et al. (2004 Dec 17). INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.

van Attikum H, et al. (2004 Dec 17). Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair.

Shevchenko A, et al. (2008). Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Hogan CJ, et al. (2010 Feb). Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism.

Duncan CD, et al. (2011 Dec). Widespread cotranslational formation of protein complexes.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02861
EOG8TQJRS

sce:SWR1

Genes: 34

SGD Description
Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction


PomBase Description
SNF2 family ATP-dependent DNA helicase Swr1


AspGD Description
Ortholog(s) have structural molecule activity, role in histone exchange, regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter and Swr1 complex, cytosol localization


References

Kitamura K, et al. (1998 May). Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase.

Yamaguchi S, et al. (2000 Aug 1). Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation.

Krogan NJ, et al. (2003 Dec). A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Mizuguchi G, et al. (2004 Jan 16). ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.

Kobor MS, et al. (2004 May). A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.

Krogan NJ, et al. (2004 Sep 14). Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4.

Shevchenko A, et al. (2008). Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

Anders A, et al. (2008 Dec). Improved tools for efficient mapping of fission yeast genes: identification of microtubule nucleation modifier mod22-1 as an allele of chromatin- remodelling factor gene swr1.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Buchanan L, et al. (2009 Nov). The Schizosaccharomyces pombe JmjC-protein, Msc1, prevents H2A.Z localization in centromeric and subtelomeric chromatin domains.

Hou H, et al. (2010 Jan 15). Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast.

Qiu X, et al. (2010 Nov 19). Activity of a C-terminal plant homeodomain (PHD) of Msc1 is essential for function.

Sadeghi L, et al. (2011 Aug). Podbat: a novel genomic tool reveals Swr1-independent H2A.Z incorporation at gene coding sequences through epigenetic meta-analysis.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Abenza JF, et al. (2014). Dynamics of cell shape inheritance in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Tapia-Alveal C, et al. (2014 Jun). H2A.Z-dependent regulation of cohesin dynamics on chromosome arms.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

George AA, et al. (2015 Dec). Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02862
EOG8TQJRS

sce:STH1

Genes: 26

SGD Description
ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p


References

Laurent BC, et al. (1992 Apr). An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family.

Tsuchiya E, et al. (1992 Nov). The Saccharomyces cerevisiae NPS1 gene, a novel CDC gene which encodes a 160 kDa nuclear protein involved in G2 phase control.

Cairns BR, et al. (1996 Dec 27). RSC, an essential, abundant chromatin-remodeling complex.

Treich I, et al. (1997 Apr). Interaction of a Swi3 homolog with Sth1 provides evidence for a Swi/Snf-related complex with an essential function in Saccharomyces cerevisiae.

Cao Y, et al. (1997 Jun). Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression.

Du J, et al. (1998 Nov). Sth1p, a Saccharomyces cerevisiae Snf2p/Swi2p homolog, is an essential ATPase in RSC and differs from Snf/Swi in its interactions with histones and chromatin-associated proteins.

Yukawa M, et al. (1999 Feb). Nps1/Sth1p, a component of an essential chromatin-remodeling complex of Saccharomyces cerevisiae, is required for the maximal expression of early meiotic genes.

Lorch Y, et al. (1999 Feb 5). Histone octamer transfer by a chromatin-remodeling complex.

Moreira JM, et al. (1999 May 17). Transcriptional repression of the yeast CHA1 gene requires the chromatin-remodeling complex RSC.

Cairns BR, et al. (1999 Nov). Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains.

Saha A, et al. (2002 Aug 15). Chromatin remodeling by RSC involves ATP-dependent DNA translocation.

Chai B, et al. (2002 Jun). Yeast RSC function is required for organization of the cellular cytoskeleton via an alternative PKC1 pathway.

Hsu JM, et al. (2003 May). The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation.

Lee KK, et al. (2004 Dec). Proteomic analysis of chromatin-modifying complexes in Saccharomyces cerevisiae identifies novel subunits.

Deutschbauer AM, et al. (2005 Dec). Quantitative trait loci mapped to single-nucleotide resolution in yeast.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Wilson B, et al. (2006 Feb). The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%