FOG02833
EOG84XGXM

sce:SLH1

Genes: 35

SGD Description
Putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses


PomBase Description
ATP-dependent RNA helicase Slh1, human ASCC3 ortholog (predicted)


AspGD Description
Ortholog(s) have mRNA binding activity, role in cytoplasmic translation, regulation of translation and cytosol, polysomal ribosome localization


References

Martegani E, et al. (1997 Mar 30). Identification of gene encoding a putative RNA-helicase, homologous to SKI2, in chromosome VII of Saccharomyces cerevisiae.

Searfoss AM, et al. (2000 Aug 1). 3' poly(A) is dispensable for translation.

Searfoss A, et al. (2001 Aug). Linking the 3' poly(A) tail to the subunit joining step of translation initiation: relations of Pab1p, eukaryotic translation initiation factor 5b (Fun12p), and Ski2p-Slh1p.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%

FOG02834
EOG84XGXM

sce:BRR2

Genes: 33

SGD Description
RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD


PomBase Description
U5 snRNP complex subunit Brr2


AspGD Description
Ortholog(s) have role in spliceosomal conformational changes to generate catalytic conformation and U5 snRNP, cytosol, spliceosomal complex localization


References

Lauber J, et al. (1996 Aug 1). The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases.

Noble SM, et al. (1996 May). Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations.

Gottschalk A, et al. (1999 Aug 16). Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.

Ohi MD, et al. (2002 Apr). Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.

Häcker I, et al. (2008 Nov). Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy.

Pena V, et al. (2009 Aug 28). Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.

Maeder C, et al. (2009 Jan). ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.

Zhang L, et al. (2009 Jul). Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2.

Hahn D, et al. (2012 Nov 1). Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%