FOG02796
EOG8SQVDP

sce:MKC7;YPS1;YPS3

Genes: 75

SGD Description
GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication|Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor|Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor


AspGD Description
Pepsin family secreted protease|Pepsin family secreted protease


References

Egel-Mitani M, et al. (1990 Mar-Apr). A novel aspartyl protease allowing KEX2-independent MF alpha propheromone processing in yeast.

Azaryan AV, et al. (1993 Jun 5). Purification and characterization of a paired basic residue-specific yeast aspartic protease encoded by the YAP3 gene. Similarity to the mammalian pro-opiomelanocortin-converting enzyme.

Cawley NX, et al. (1995 Jun 6). Secretion of yeast aspartic protease 3 is regulated by its carboxy-terminal tail: characterization of secreted YAP3p.

Komano H, et al. (1995 Nov 7). Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast.

Ash J, et al. (1995 Sep 1). The yeast proprotein convertase encoded by YAP3 is a glycophosphatidylinositol-anchored protein that localizes to the plasma membrane.

Cawley NX, et al. (1998 Jan 2). Activation and processing of non-anchored yapsin 1 (Yap3p).

Olsen V, et al. (1998 Mar 3). Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: correlation with electronegative active-site pockets predicted by molecular modeling.

Monod M, et al. (1998 Oct). Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans.

Olsen V, et al. (1999 Apr 15). Identification and characterization of Saccharomyces cerevisiae yapsin 3, a new member of the yapsin family of aspartic proteases encoded by the YPS3 gene.

Komano H, et al. (1999 Aug 20). Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p).

Terashima H, et al. (2000 Sep). Up-regulation of genes encoding glycosylphosphatidylinositol (GPI)-attached proteins in response to cell wall damage caused by disruption of FKS1 in Saccharomyces cerevisiae.

Sievi E, et al. (2001 Dec). Proteolytic function of GPI-anchored plasma membrane protease Yps1p in the yeast vacuole and Golgi.

Frieman MB, et al. (2003 Nov). The omega-site sequence of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae can determine distribution between the membrane and the cell wall.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Krysan DJ, et al. (2005 Aug). Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.

Machida M, et al. (2005 Dec 22). Genome sequencing and analysis of Aspergillus oryzae.

Copping VM, et al. (2005 May). Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes.

Albrecht A, et al. (2006 Jan 13). Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions.

Gagnon-Arsenault I, et al. (2008 Aug). Activation mechanism, functional role and shedding of glycosylphosphatidylinositol-anchored Yps1p at the Saccharomyces cerevisiae cell surface.

Wang Y, et al. (2008 Jan). Isolation of four pepsin-like protease genes from Aspergillus niger and analysis of the effect of disruptions on heterologous laccase expression.

Vadaie N, et al. (2008 Jun 30). Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast.

Hornbach A, et al. (2009 Dec). The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils.

Sorgo AG, et al. (2011 Aug). Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.

Aoki W, et al. (2011 Oct). Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.

de Souza WR, et al. (2013). Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans.

Bocheńska O, et al. (2013 Oct). Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 47 genes with posterior transmembrane prediction > 50%

FOG02797
EOG8SQVDP

sce:absent

Genes: 5

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02798
EOG8SQVDP

sce:BAR1

Genes: 3

SGD Description
Aspartyl protease; secreted into the periplasmic space of mating type a cell; helps cells find mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest


References

MacKay VL, et al. (1988 Jan). The Saccharomyces cerevisiae BAR1 gene encodes an exported protein with homology to pepsin.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02799
EOG8SQVDP

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02800
EOG8SQVDP
EOG8VX0NS

sce:absent

Genes: 50

References

White TC, et al. (1993 Oct). Three distinct secreted aspartyl proteinases in Candida albicans.

Smolenski G, et al. (1997 Feb). Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes.

De Bernardis F, et al. (1999 Jan). Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis.

Schaller M, et al. (2001 Aug). Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo.

Felk A, et al. (2002 Jul). Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs.

Jackson BE, et al. (2007 Aug). The role of secreted aspartyl proteinases in Candida albicans keratitis.

Borelli C, et al. (2007 Aug 15). The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A.

Gropp K, et al. (2009 Dec). The yeast Candida albicans evades human complement attack by secretion of aspartic proteases.

Pietrella D, et al. (2010 Nov). The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity.

Glittenberg MT, et al. (2011 Jul). Pathogen and host factors are needed to provoke a systemic host response to gastrointestinal infection of Drosophila larvae by Candida albicans.

Aoki W, et al. (2011 Oct). Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.

Staniszewska M, et al. (2012). In vitro study of secreted aspartyl proteinases Sap1 to Sap3 and Sap4 to Sap6 expression in Candida albicans pleomorphic forms.

Ramage G, et al. (2012 Jul). In vitro Candida albicans biofilm induced proteinase activity and SAP8 expression correlates with in vivo denture stomatitis severity.

Cadicamo CD, et al. (2013 Apr 1). Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans.

Bocheńska O, et al. (2013 Oct). Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG02801
EOG873NG8
EOG8SQVDP

sce:absent

Genes: 9

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG02802
EOG8SQVDP

sce:absent

Genes: 4

References

García-Sánchez S, et al. (2005 Jun). Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.

Taylor BN, et al. (2005 Oct). Induction of SAP7 correlates with virulence in an intravenous infection model of candidiasis but not in a vaginal infection model in mice.

Aoki W, et al. (2011 Oct). Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.

Aoki W, et al. (2012). Candida albicans possesses Sap7 as a pepstatin A-insensitive secreted aspartic protease.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02803
EOG8SQVDP

sce:absent

Genes: 4

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02804
EOG8SQVDP

sce:absent

Genes: 3

References

Young TW, et al. (1996 Oct). The extracellular acid protease gene of Yarrowia lipolytica: sequence and pH-regulated transcription.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02805
EOG8SQVDP

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02806
EOG8SQVDP

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02807
EOG8VX0NS

sce:PEP4

Genes: 33

SGD Description
Vacuolar aspartyl protease (proteinase A); required for posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates


AspGD Description
Putative acid aspartic protease, constitutively expressed


References

Ammerer G, et al. (1986 Jul). PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.

Woolford CA, et al. (1986 Jul). The PEP4 gene encodes an aspartyl protease implicated in the posttranslational regulation of Saccharomyces cerevisiae vacuolar hydrolases.

Rupp S, et al. (1991 Nov 18). Biogenesis of the yeast vacuole (lysosome). Active site mutation in the vacuolar aspartate proteinase yscA blocks maturation of vacuolar proteinases.

Roof DM, et al. (1992 Jul). Kinesin-related proteins required for assembly of the mitotic spindle.

Wolff AM, et al. (1996 Jul). Vacuolar and extracellular maturation of Saccharomyces cerevisiae proteinase A.

Aguilar CF, et al. (1997 Apr 11). The three-dimensional structure at 2.4 A resolution of glycosylated proteinase A from the lysosome-like vacuole of Saccharomyces cerevisiae.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Machida M, et al. (2005 Dec 22). Genome sequencing and analysis of Aspergillus oryzae.

Hortschansky P, et al. (2007 Jul 11). Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.

Wang Y, et al. (2008 Jan). Isolation of four pepsin-like protease genes from Aspergillus niger and analysis of the effect of disruptions on heterologous laccase expression.

Martins I, et al. (2013 Dec 6). Proteomic alterations induced by ionic liquids in Aspergillus nidulans and Neurospora crassa.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02808
EOG8VX0NS
EOG8W6MBT

sce:absent

Genes: 22

AspGD Description
Pepsin family secreted protease; expression repressed by tunicamycin and DTT


References

Machida M, et al. (2005 Dec 22). Genome sequencing and analysis of Aspergillus oryzae.

Wang Y, et al. (2008 Jan). Isolation of four pepsin-like protease genes from Aspergillus niger and analysis of the effect of disruptions on heterologous laccase expression.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 12 genes with posterior transmembrane prediction > 50%

FOG02809
EOG8W6MBT

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02810
EOG8SQVDP

sce:YPS6

Genes: 4

SGD Description
Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance


References

Hamada K, et al. (1999 Jul). Amino acid residues in the omega-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins.

Krysan DJ, et al. (2005 Aug). Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.

Kung LA, et al. (2009). Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02811
EOG8VX0NS

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted aspartic-type endopeptidase activity and role in proteolysis

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02812
EOG82RBQN
EOG88933M

sce:absent

Genes: 2

PomBase Description
aspartic protease Sxa1|aspartic protease, yapsin Yps1


References

Imai Y, et al. (1992 Apr). Schizosaccharomyces pombe sxa1+ and sxa2+ encode putative proteases involved in the mating response.

Hughes M, et al. (1997 May). The role of Sxa1 in pheromone recovery in Schizosaccharomyces pombe.

Ladds G, et al. (1998 Apr). Extracellular degradation of agonists as an adaptive mechanism.

Tsukahara K, et al. (1998 Aug). An RNA binding protein negatively controlling differentiation in fission yeast.

Ding DQ, et al. (2000 Mar). Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.

Ladds G, et al. (2000 Nov). Identification of proteases with shared functions to the proprotein processing protease Krp1 in the fission yeast Schizosaccharomyces pombe.

De Groot PW, et al. (2003 Jul 15). Genome-wide identification of fungal GPI proteins.

Wang Y, et al. (2008 Jan). Isolation of four pepsin-like protease genes from Aspergillus niger and analysis of the effect of disruptions on heterologous laccase expression.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02813


sce:absent

Genes: 8

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02814
EOG8DV483
EOG8Z08NN

sce:absent

Genes: 4

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%