FOG02789
EOG8DJHBB
sce:SNU114
Genes: 33
EOG8DJHBB
sce:SNU114
Genes: 33
SGD Description
GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
PomBase Description
U5 snRNP GTPase subunit Cwf10
AspGD Description
Ortholog(s) have role in regulation of heterochromatin domain assembly and Prp19 complex, U5 snRNP, cytosol, spliceosomal complex localization
References
Fabrizio P, et al. (1997 Jul 1). An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.
Gottschalk A, et al. (1999 Aug 16). Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.
Ohi MD, et al. (2002 Apr). Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.
Häcker I, et al. (2008 Nov). Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy.
Grainger RJ, et al. (2009 Dec). Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
5 genes with posterior transmembrane prediction > 50% |
||
FOG02790
EOG8DJHBB
sce:RIA1
Genes: 33
EOG8DJHBB
sce:RIA1
Genes: 33
SGD Description
Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
PomBase Description
GTPase Ria1 (predicted)
AspGD Description
Ortholog(s) have GTPase activity, role in mature ribosome assembly and cytosol localization
References
Senger B, et al. (2001 Dec). The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.
Bécam AM, et al. (2001 Nov). Ria1p (Ynl163c), a protein similar to elongation factors 2, is involved in the biogenesis of the 60S subunit of the ribosome in Saccharomyces cerevisiae.
Graindorge JS, et al. (2005 Sep 16). Deletion of EFL1 results in heterogeneity of the 60 S GTPase-associated rRNA conformation.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
17 genes with posterior transmembrane prediction > 50% |
||
FOG02791
EOG8254C2
sce:YIF1
Genes: 32
EOG8254C2
sce:YIF1
Genes: 32
SGD Description
Integral membrane protein; required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3
PomBase Description
COPII-coated vesicle component Hrf1 (predicted)
AspGD Description
Ortholog(s) have role in establishment or maintenance of cell polarity, negative regulation of G0 to G1 transition
References
Matern H, et al. (2000 Sep 1). A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting.
Otte S, et al. (2001 Feb 5). Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex.
Calero M, et al. (2002 Mar 27). Identification of the novel proteins Yip4p and Yip5p as Rab GTPase interacting factors.
Chattopadhyay S, et al. (2003 Mar 14). The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p.
Barrowman J, et al. (2003 May 30). The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles.
Vollert CS, et al. (2004 Nov). The phox homology (PX) domain protein interaction network in yeast.
Inadome H, et al. (2005 Sep). Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Sajiki K, et al. (2009 May 1). Genetic control of cellular quiescence in S. pombe.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
32 genes with posterior transmembrane prediction > 50% |
||
FOG02792
EOG8DJHBB
sce:EFT1; EFT2
Genes: 35
EOG8DJHBB
sce:EFT1; EFT2
Genes: 35
PomBase Description
translation elongation factor 2 (EF-2) Eft2,A
AspGD Description
Translation elongation factor 2; protein levels influenced by presence of starch
References
Van Ness BG, et al. (1978 Dec 25). Isolation and properties of the trypsin-derived ADP-ribosyl peptide from diphtheria toxin-modified yeast elongation factor 2.
Donovan MG, et al. (1991 Oct 21). Saccharomyces cerevisiae elongation factor 2 is phosphorylated by an endogenous kinase.
Perentesis JP, et al. (1992 Jan 15). Saccharomyces cerevisiae elongation factor 2. Genetic cloning, characterization of expression, and G-domain modeling.
Phan LD, et al. (1993 Apr 25). Saccharomyces cerevisiae elongation factor 2. Mutagenesis of the histidine precursor of diphthamide yields a functional protein that is resistant to diphtheria toxin.
Kimata Y, et al. (1993 Mar 31). Expression of non-ADP-ribosylatable, diphtheria toxin-resistant elongation factor 2 in Saccharomyces cerevisiae.
Justice MC, et al. (1998 Feb 6). Elongation factor 2 as a novel target for selective inhibition of fungal protein synthesis.
Shastry M, et al. (2001 Feb). Species-specific inhibition of fungal protein synthesis by sordarin: identification of a sordarin-specificity region in eukaryotic elongation factor 2.
Lalioti VS, et al. (2002 Nov). Characterization of interaction sites in the Saccharomyces cerevisiae ribosomal stalk components.
Jørgensen R, et al. (2003 May). Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase.
Diezmann S, et al. (2004 Dec). Phylogeny and evolution of medical species of Candida and related taxa: a multigenic analysis.
Spahn CM, et al. (2004 Mar 10). Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.
Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.
Jørgensen R, et al. (2004 Oct 29). Crystal structure of ADP-ribosylated ribosomal translocase from Saccharomyces cerevisiae.
Asp E, et al. (2008 Feb). Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors.
Nahlik K, et al. (2010 Nov). The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development.
Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.
Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Couttas TA, et al. (2012 Apr). Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases.
Hekman KE, et al. (2012 Dec 15). A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Jongjitwimol J, et al. (2014). The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.
Zhang L, et al. (2014 Aug 22). Elongation factor methyltransferase 3--a novel eukaryotic lysine methyltransferase.
Hart-Smith G, et al. (2014 Mar 7). Stoichiometry of Saccharomyces cerevisiae lysine methylation: insights into non-histone protein lysine methyltransferase activity.
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
||
