FOG02748
EOG8280GX

sce:PMR1

Genes: 35

SGD Description
High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen appears to be required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease


PomBase Description
P-type ATPase, calcium transporting Pmr1


AspGD Description
P-type Ca2+-ATPase involved in the secretory pathway


References

Rudolph HK, et al. (1989 Jul 14). The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family.

Na JG, et al. (1992 Aug). Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae.

Park CS, et al. (1998 Jan 5). Molecular cloning of YlPMR1, a S. cerevisiae PMR1 homologue encoding a novel P-type secretory pathway Ca2+ -ATPase, in the yeast Yarrowia lipolytica.

Maeda T, et al. (2004 Jan). Pmr1, a P-type ATPase, and Pdt1, an Nramp homologue, cooperatively regulate cell morphogenesis in fission yeast: the importance of Mn2+ homeostasis.

Cortés JC, et al. (2004 Oct). Schizosaccharomyces pombe Pmr1p is essential for cell wall integrity and is required for polarized cell growth and cytokinesis.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Hagiwara D, et al. (2008 Dec). Functional analysis of C2H2 zinc finger transcription factor CrzA involved in calcium signaling in Aspergillus nidulans.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Furune T, et al. (2008 Oct). Characterization of a fission yeast P(5)-type ATPase homologue that is essential for Ca(2+)/Mn(2+ )homeostasis in the absence of P(2)-type ATPases.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Ma Y, et al. (2011). Transient receptor potential (TRP) and Cch1-Yam8 channels play key roles in the regulation of cytoplasmic Ca2+ in fission yeast.

Gao L, et al. (2011 Nov). Osmotic stabilizer-coupled suppression of NDR defects is dependent on the calcium-calcineurin signaling cascade in Aspergillus nidulans.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Jiang H, et al. (2014 Nov). Putative PmrA and PmcA are important for normal growth, morphogenesis and cell wall integrity, but not for viability in Aspergillus nidulans.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Gaspa L, et al. (2016). A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 35 genes with posterior transmembrane prediction > 50%

FOG02749
EOG8280GX

sce:PMC1

Genes: 40

SGD Description
Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a


PomBase Description
vacuolar calcium transporting P-type ATPase P2 type, Pmc1


AspGD Description
Putative vacuolar Ca2+/H+ exchanger|Putative calcium-transporting ATPase|Calcium-transporting ATPase


References

Cunningham KW, et al. (1994 Feb). Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases.

Hagiwara D, et al. (2008 Dec). Functional analysis of C2H2 zinc finger transcription factor CrzA involved in calcium signaling in Aspergillus nidulans.

Savoldi M, et al. (2008 Oct). Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Soriani FM, et al. (2010 Jan 15). Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA.

Findon H, et al. (2010 Jul). Analysis of a novel calcium auxotrophy in Aspergillus nidulans.

Almeida RS, et al. (2013 Jul 8). Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis.

Jiang H, et al. (2014 Nov). Putative PmrA and PmcA are important for normal growth, morphogenesis and cell wall integrity, but not for viability in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 40 genes with posterior transmembrane prediction > 50%

FOG02750
EOG8280GX
EOG8B5MMC

sce:COG4

Genes: 33

SGD Description
Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments


PomBase Description
Golgi transport complex subunit Cog4 (predicted)


AspGD Description
Ortholog(s) have role in CVT pathway, establishment of cell polarity, filamentous growth of a population of unicellular organisms, pexophagy, retrograde transport, vesicle recycling within Golgi


References

Kim DW, et al. (2001 Nov). Sgf1p, a new component of the Sec34p/Sec35p complex.

Whyte JR, et al. (2001 Oct). The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.

Cronin SR, et al. (2002 Jun 10). Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis.

Ram RJ, et al. (2002 May). Identification of Sec36p, Sec37p, and Sec38p: components of yeast complex that contains Sec34p and Sec35p.

Suvorova ES, et al. (2002 May 13). The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins.

Loh E, et al. (2004 Jun 4). The binary interacting network of the conserved oligomeric Golgi tethering complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG02751
EOG8280GX

sce:absent

Genes: 8

AspGD Description
Ortholog(s) have calcium-transporting ATPase activity and nuclear envelope localization


References

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 8 genes with posterior transmembrane prediction > 50%