FOG02718
EOG80CG3F
EOG8547K4

sce:MPC2;MPC3

Genes: 34

SGD Description
Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Mpc1p and either Mpc2p or Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; MPC2 has a paralog, FMP43, that arose from the whole genome duplication|Highly conserved subunit of mitochondrial pyruvate carrier; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress; MPC3 has a paralog, MPC2, that arose from the whole genome duplication


PomBase Description
mitochondrial pyruvate transmembrane transporter Mpc2 (predicted)


AspGD Description
Ortholog(s) have pyruvate transmembrane transporter activity, role in mitochondrial pyruvate transport and mitochondrial membrane, plasma membrane localization


References

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Viladevall L, et al. (2004 Oct 15). Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae.

Proft M, et al. (2005 Aug). Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae.

Liu X, et al. (2007 Apr). Genetic and comparative transcriptome analysis of bromodomain factor 1 in the salt stress response of Saccharomyces cerevisiae.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Bricker DK, et al. (2012 Jul 6). A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.

Herzig S, et al. (2012 Jul 6). Identification and functional expression of the mitochondrial pyruvate carrier.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%

FOG02719
EOG80CG3F
EOG8547K4

sce:MPC1

Genes: 32

SGD Description
Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Mpc1p and either Mpc2p or Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia


PomBase Description
mitochondrial pyruvate transmembrane transporter subunit Mpc1 (predicted)


AspGD Description
Ortholog(s) have pyruvate transmembrane transporter activity, role in mitochondrial pyruvate transport and integral component of mitochondrial inner membrane localization


References

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Bricker DK, et al. (2012 Jul 6). A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.

Herzig S, et al. (2012 Jul 6). Identification and functional expression of the mitochondrial pyruvate carrier.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%