FOG02683
EOG8X3FJH

sce:ARR3

Genes: 28

SGD Description
Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite


AspGD Description
Has domain(s) with predicted antiporter activity, bile acid:sodium symporter activity, inorganic anion transmembrane transporter activity, role in sodium ion transport and integral component of membrane, membrane localization


References

Bobrowicz P, et al. (1997 Jul). Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae.

Wysocki R, et al. (1997 Nov 28). The Saccharomyces cerevisiae ACR3 gene encodes a putative membrane protein involved in arsenite transport.

Maciaszczyk-Dziubinska E, et al. (2010 Nov). The yeast permease Acr3p is a dual arsenite and antimonite plasma membrane transporter.

Maciaszczyk-Dziubinska E, et al. (2011 Jul). Acr3p is a plasma membrane antiporter that catalyzes As(III)/H(+) and Sb(III)/H(+) exchange in Saccharomyces cerevisiae.

Duan G, et al. (2012 Jan). Expressing ScACR3 in rice enhanced arsenite efflux and reduced arsenic accumulation in rice grains.

Ali W, et al. (2012 May). Heterologous expression of the yeast arsenite efflux system ACR3 improves Arabidopsis thaliana tolerance to arsenic stress.

Maciaszczyk-Dziubinska E, et al. (2014 Mar). Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces cerevisiae.

Markowska K, et al. (2015 Oct). Identification of critical residues for transport activity of Acr3p, the Saccharomyces cerevisiae As(III)/H+ antiporter.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 28 genes with posterior transmembrane prediction > 50%