FOG02673
EOG8RN8R1

sce:TPN1

Genes: 38

SGD Description
Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p


AspGD Description
Ortholog(s) have vitamin transporter activity, role in vitamin transport and plasma membrane localization|Has domain(s) with predicted nucleobase transmembrane transporter activity, transporter activity, role in nucleobase transport, transmembrane transport and integral component of membrane, membrane localization|Has domain(s) with predicted nucleobase transmembrane transporter activity, transporter activity, role in nucleobase transport, transmembrane transport and integral component of membrane, membrane localization|Ortholog(s) have cytidine transmembrane transporter activity, drug transmembrane transporter activity, nucleobase transmembrane transporter activity


References

Stolz J, et al. (2003 May 23). Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Hamari Z, et al. (2009 Jul). Convergent evolution and orphan genes in the Fur4p-like family and characterization of a general nucleoside transporter in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 38 genes with posterior transmembrane prediction > 50%

FOG02674
EOG8RN8R1

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02675
EOG8RN8R1

sce:FCY21;FCY22;FCY2

Genes: 44

SGD Description
Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function|Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function|Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress


AspGD Description
Ortholog(s) have role in purine nucleobase transport


References

Hinnebusch AG, et al. (1983 Apr 25). Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae.

Weber E, et al. (1990 Apr). The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product.

Rodriguez C, et al. (1995 Jan). The immunodetected yeast purine-cytosine permease is not N-linked glycosylated, nor are glycosylation sequences required to have a functional permease.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Pantazopoulou A, et al. (2007 Nov). Fungal nucleobase transporters.

Vlanti A, et al. (2008 May). The Aspergillus nidulans FcyB cytosine-purine scavenger is highly expressed during germination and in reproductive compartments and is downregulated by endocytosis.

Hamari Z, et al. (2009 Jul). Convergent evolution and orphan genes in the Fur4p-like family and characterization of a general nucleoside transporter in Aspergillus nidulans.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Krypotou E, et al. (2012 Oct 26). Modeling, substrate docking, and mutational analysis identify residues essential for the function and specificity of a eukaryotic purine-cytosine NCS1 transporter.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 44 genes with posterior transmembrane prediction > 50%

FOG02676
EOG8KWH8C

sce:absent

Genes: 4

References

Hamari Z, et al. (2009 Jul). Convergent evolution and orphan genes in the Fur4p-like family and characterization of a general nucleoside transporter in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%