FOG02665
EOG80000C
EOG83XSJX

sce:PHO87;PHO90;PHO91

Genes: 53

SGD Description
Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of the PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication|Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication|Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth


PomBase Description
sodium ion transmembrane transporter (predicted)


AspGD Description
Putative arsenite efflux transporter


References

Kern L, et al. (1990 Sep 11). The URK1 gene of Saccharomyces cerevisiae encoding uridine kinase.

Bun-ya M, et al. (1996 Mar). Two new genes, PHO86 and PHO87, involved in inorganic phosphate uptake in Saccharomyces cerevisiae.

Wykoff DD, et al. (2001 Dec). Phosphate transport and sensing in Saccharomyces cerevisiae.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Auesukaree C, et al. (2003 Jul 11). Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Hürlimann HC, et al. (2007 Nov). Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces cerevisiae.

Estrella LA, et al. (2008 Feb 29). The Rsp5 E3 ligase mediates turnover of low affinity phosphate transporters in Saccharomyces cerevisiae.

Popova Y, et al. (2010 Feb 16). Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 53 genes with posterior transmembrane prediction > 50%

FOG02666
EOG83XSJX

sce:VAM6

Genes: 5

SGD Description
Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p, facilitating tethering and promoting several membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking


References

Nakamura N, et al. (1997 Apr 25). Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae.

Stroupe C, et al. (2006 Apr 19). Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02667
EOG83XSJX

sce:absent

Genes: 25

PomBase Description
guanyl-nucleotide exchange factor, HOPS complex subunit Vam6 (predicted)


AspGD Description
Ortholog(s) have role in vacuole organization and cytosol, nucleus localization


References

Oka M, et al. (2004 Mar 12). Molecular cloning and functional characterization of avaB, a gene encoding Vam6p/Vps39p-like protein in Aspergillus nidulans.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Abenza JF, et al. (2012 May). Endosomal maturation by Rab conversion in Aspergillus nidulans is coupled to dynein-mediated basipetal movement.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%