FOG02649
EOG84QRFW

sce:CCC2

Genes: 33

SGD Description
Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant


PomBase Description
copper transporting ATPase Ccc2 (predicted)


AspGD Description
Ortholog(s) have cation-transporting ATPase activity, copper ion binding activity and role in cellular iron ion homeostasis, copper ion export, pigment metabolic process involved in developmental pigmentation


References

Clutterbuck AJ, et al. (1972 May). Absence of laccase from yellow-spored mutants of Aspergillus nidulans.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Clutterbuck AJ, et al. (1990 Sep). The genetics of conidiophore pigmentation in Aspergillus nidulans.

Fu D, et al. (1995 Mar). Sequence, mapping and disruption of CCC2, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants and encodes a P-type ATPase belonging to the Cu(2+)-ATPase subfamily.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Banci L, et al. (2001 Mar 16). Solution structure of the yeast copper transporter domain Ccc2a in the apo and Cu(I)-loaded states.

Arnesano F, et al. (2001 Nov 2). Characterization of the binding interface between the copper chaperone Atx1 and the first cytosolic domain of Ccc2 ATPase.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG02650
EOG84QRFW

sce:absent

Genes: 24

AspGD Description
Ortholog(s) have copper-exporting ATPase activity, role in cadmium ion transport, cellular copper ion homeostasis, copper ion transport, silver ion transport and plasma membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 24 genes with posterior transmembrane prediction > 50%

FOG02651
EOG84QRFW

sce:PCA1

Genes: 5

SGD Description
Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function


References

Tohoyama H, et al. (1990 Oct). Resistance to cadmium is under control of the CAD2 gene in the yeast Saccharomyces cerevisiae.

Rad MR, et al. (1994 Sep). A putative P-type Cu(2+)-transporting ATPase gene on chromosome II of Saccharomyces cerevisiae.

Shiraishi E, et al. (2000 Feb). The cadmium-resistant gene, CAD2, which is a mutated putative copper-transporter gene (PCA1), controls the intracellular cadmium-level in the yeast S. cerevisiae.

De Freitas JM, et al. (2004 Feb 6). Exploratory and confirmatory gene expression profiling of mac1Delta.

Adle DJ, et al. (2007 Jan 12). A cadmium-transporting P1B-type ATPase in yeast Saccharomyces cerevisiae.

Adle DJ, et al. (2008 Nov 14). Expressional control of a cadmium-transporting P1B-type ATPase by a metal sensing degradation signal.

Chang SL, et al. (2011 Mar). A tradeoff drives the evolution of reduced metal resistance in natural populations of yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%

FOG02652
EOG84QRFW

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%