FOG02634
EOG8SN04S

sce:NHA1

Genes: 39

SGD Description
Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH


PomBase Description
plasma membrane alkali metal cation/H+ antiporter Sod22


AspGD Description
Ortholog(s) have potassium:proton antiporter activity, sodium:proton antiporter activity


References

Prior C, et al. (1996 May 27). Characterization of the NHA1 gene encoding a Na+/H+-antiporter of the yeast Saccharomyces cerevisiae.

Kamauchi S, et al. (2002 Jun). Structurally and functionally conserved domains in the diverse hydrophilic carboxy-terminal halves of various yeast and fungal Na+/H+ antiporters (Nha1p).

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Findon H, et al. (2010 Jul). Analysis of a novel calcium auxotrophy in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 39 genes with posterior transmembrane prediction > 50%

FOG02635
EOG8SN04S

sce:absent

Genes: 8

AspGD Description
Has domain(s) with predicted solute:proton antiporter activity, role in cation transport, transmembrane transport and integral component of membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 8 genes with posterior transmembrane prediction > 50%

FOG02636
EOG8SN04S

sce:absent

Genes: 3

PomBase Description
plasma membrane sodium ion/proton antiporter Sod2


AspGD Description
Has domain(s) with predicted solute:proton antiporter activity, role in cation transport, transmembrane transport and integral component of membrane localization


References

Jia ZP, et al. (1992 Apr). Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.

Balcells L, et al. (1997 Dec 1). Regulation of salt tolerance in fission yeast by a protein-phosphatase-Z-like Ser/Thr protein phosphatase.

Dibrov P, et al. (1997 Mar 17). Identification and localization of the sod2 gene product in fission yeast.

Saleki R, et al. (1997 May 20). Tolerance of low pH in Schizosaccharomyces pombe requires a functioning pub1 ubiquitin ligase.

Dibrov P, et al. (1998 Jun). Physiological consequences of expression of the Na+/H+ antiporter sod2 in Escherichia coli.

Dibrov P, et al. (1998 Jun 9). Functional analysis of amino acid residues essential for activity in the Na+/H+ exchanger of fission yeast.

Balcells L, et al. (1999 Feb). The Schizosaccharomyces pombe Pzh1 protein phosphatase regulates Na+ ion influx in a Trk1-independent fashion.

Miyamoto R, et al. (2000 Jul). Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophy.

Wiebe CA, et al. (2003 Dec). Functional analysis of amino acids of the Na+/H+ exchanger that are important for proton translocation.

Fliegel L, et al. (2005 Jan). Identification of conserved polar residues important for salt tolerance by the Na+/H+ exchanger of Schizosaccharomyces pombe.

Fliegel L, et al. (2005 Jul). Functional expression and cellular localization of the Na+/H+ exchanger Sod2 of the fission yeast Schizosaccharomyces pombe.

Wang LY, et al. (2005 May). Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase.

Chen H, et al. (2008 Dec). Expression, purification, and reconstitution of the Na(+)/H (+) exchanger sod2 in Saccharomyces cerevisiae.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Ndayizeye M, et al. (2009 May). Proline 146 is critical to the structure, function and targeting of sod2, the Na+/H+ exchanger of Schizosaccharomyces pombe.

Kashiwazaki J, et al. (2011 Oct). Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.

Ullah A, et al. (2013 Aug 23). Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Ullah A, et al. (2014 Jan). Functional role and analysis of cysteine residues of the salt tolerance protein Sod2.

Alao JP, et al. (2015). Suppression of sensitivity to drugs and antibiotics by high external cation concentrations in fission yeast.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%