FOG02585
EOG8GQNMH

sce:absent

Genes: 34

PomBase Description
transmembrane transporter (predicted)


AspGD Description
Ortholog(s) have purine nucleobase binding, urate transmembrane transporter activity, xanthine transmembrane transporter activity and role in cellular response to ammonium ion, urate transport, xanthine transport


References

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Arst HN Jr, et al. (1975 Mar 6). Initiator constitutive mutation with an 'up-promoter' effect in Aspergillus nidulans.

Scazzocchio C, et al. (1978 Jul 13). The nature of an initiator constitutive mutation in Aspergillus nidulans.

Wiame JM, et al. (1985). Nitrogen catabolite repression in yeasts and filamentous fungi.

Arst HN Jr, et al. (1988 Aug). Localisation of several chromosome I genes of Aspergillus nidulans: implications for mitotic recombination.

Diallinas G, et al. (1989 Jun). A gene coding for the uric acid-xanthine permease of Aspergillus nidulans: inactivational cloning, characterization, and sequence of a cis-acting mutation.

Suárez T, et al. (1991 Dec). Molecular cloning of the uaY regulatory gene of Aspergillus nidulans reveals a favoured region for DNA insertions.

Gorfinkiel L, et al. (1993 Nov 5). Sequence and regulation of the uapA gene encoding a uric acid-xanthine permease in the fungus Aspergillus nidulans.

Diallinas G, et al. (1994). Genetic and molecular characterisation of purine permease genes of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.

Scazzocchio C, et al. (1994). The purine degradation pathway, genetics, biochemistry and regulation.

Diallinas G, et al. (1995 Apr 14). Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.

Suárez T, et al. (1995 Apr 3). The sequence and binding specificity of UaY, the specific regulator of the purine utilization pathway in Aspergillus nidulans, suggest an evolutionary relationship with the PPR1 protein of Saccharomyces cerevisiae.

Oestreicher N, et al. (1995 Jun 16). A single amino acid change in a pathway-specific transcription factor results in differing degrees of constitutivity, hyperinducibility and derepression of several structural genes.

Ravagnani A, et al. (1997 Jul 1). Subtle hydrophobic interactions between the seventh residue of the zinc finger loop and the first base of an HGATAR sequence determine promoter-specific recognition by the Aspergillus nidulans GATA factor AreA.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Oestreicher N, et al. (1997 Jun). Mutations in a dispensable region of the UaY transcription factor of Aspergillus nidulans differentially affect the expression of structural genes.

Diallinas G, et al. (1998 Jul 15). Chimeric purine transporters of Aspergillus nidulans define a domain critical for function and specificity conserved in bacterial, plant and metazoan homologues.

Dessen P, et al. (2000 Feb 22). The PAUSE software for analysis of translational control over protein targeting: application to E. nidulans membrane proteins.

Meintanis C, et al. (2000 Jan-Mar). Amino acid residues N450 and Q449 are critical for the uptake capacity and specificity of UapA, a prototype of a nucleobase-ascorbate transporter family.

Valdez-Taubas J, et al. (2000 Jul). Protein expression and subcellular localization of the general purine transporter UapC from Aspergillus nidulans.

Ribard C, et al. (2001 Dec). The oxpA5 mutation of Aspergillus nidulans is an allele of adB, the gene encoding adenylosuccinate synthetase.

Amillis S, et al. (2001 Nov 2). Substitution F569S converts UapA, a specific uric acid-xanthine transporter, into a broad specificity transporter for purine-related solutes.

Amillis S, et al. (2004 Apr). Transcription of purine transporter genes is activated during the isotropic growth phase of Aspergillus nidulans conidia.

Valdez-Taubas J, et al. (2004 Jan). Ammonium-induced internalisation of UapC, the general purine permease from Aspergillus nidulans.

Cecchetto G, et al. (2004 Jan 30). The AzgA purine transporter of Aspergillus nidulans. Characterization of a protein belonging to a new phylogenetic cluster.

Koukaki M, et al. (2005 Jul 15). The nucleobase-ascorbate transporter (NAT) signature motif in UapA defines the function of the purine translocation pathway.

Goudela S, et al. (2005 May-Jun). Comparative substrate recognition by bacterial and fungal purine transporters of the NAT/NCS2 family.

Karatza P, et al. (2005 May-Jun). Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coli.

David H, et al. (2006). Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans.

Pantazopoulou A, et al. (2006 Jul-Aug). The first transmembrane segment (TMS1) of UapA contains determinants necessary for expression in the plasma membrane and purine transport.

Vlanti A, et al. (2006 Mar 31). A novel-type substrate-selectivity filter and ER-exit determinants in the UapA purine transporter.

Pantazopoulou A, et al. (2007 Jul). Differential physiological and developmental expression of the UapA and AzgA purine transporters in Aspergillus nidulans.

Amillis S, et al. (2007 May-Jun). Regulation of expression and kinetic modeling of substrate interactions of a uracil transporter in Aspergillus nidulans.

Pantazopoulou A, et al. (2007 Nov). Fungal nucleobase transporters.

Oestreicher N, et al. (2008 May). The nadA gene of Aspergillus nidulans, encoding adenine deaminase, is subject to a unique regulatory pattern.

Vlanti A, et al. (2008 May). The Aspergillus nidulans FcyB cytosine-purine scavenger is highly expressed during germination and in reproductive compartments and is downregulated by endocytosis.

Papageorgiou I, et al. (2008 Oct 24). Specific interdomain synergy in the UapA transporter determines its unique specificity for uric acid among NAT carriers.

Lemuh ND, et al. (2009 Jan). Purification and partial characterization of the xanthine-uric acid transporter (UapA) of Aspergillus nidulans.

Hamari Z, et al. (2009 Jul). Convergent evolution and orphan genes in the Fur4p-like family and characterization of a general nucleoside transporter in Aspergillus nidulans.

Kosti V, et al. (2010 Apr 16). Dynamic elements at both cytoplasmically and extracellularly facing sides of the UapA transporter selectively control the accessibility of substrates to their translocation pathway.

Gournas C, et al. (2010 Jan). Transport-dependent endocytosis and turnover of a uric acid-xanthine permease.

Leung J, et al. (2010 Jul). Expression and purification of a functional uric acid-xanthine transporter (UapA).

Gournas C, et al. (2011 Aug). Completing the purine utilisation pathway of Aspergillus nidulans.

Amillis S, et al. (2011 Aug 19). Mutational analysis and modeling reveal functionally critical residues in transmembrane segments 1 and 3 of the UapA transporter.

Bitsikas V, et al. (2011 Jan). Hypertonic conditions trigger transient plasmolysis, growth arrest and blockage of transporter endocytosis in Aspergillus nidulans and Saccharomyces cerevisiae.

Kosti V, et al. (2012). Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family.

Karachaliou M, et al. (2013 Apr). The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals.

Fang W, et al. (2013 Aug). Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target.

Leung J, et al. (2013 Feb). Stabilizing the heterologously expressed uric acid-xanthine transporter UapA from the lower eukaryote Aspergillus nidulans.

Diallinas G, et al. (2013 Sep). Allopurinol and xanthine use different translocation mechanisms and trajectories in the fungal UapA transporter.

Diallinas G, et al. (2014). Understanding transporter specificity and the discrete appearance of channel-like gating domains in transporters.

Martzoukou O, et al. (2015 Aug 14). Oligomerization of the UapA Purine Transporter Is Critical for ER-Exit, Plasma Membrane Localization and Turnover.

Krypotou E, et al. (2015 Feb). Functional characterization of NAT/NCS2 proteins of Aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%

FOG02586
EOG8GQNMH

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted transporter activity, role in transmembrane transport and membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%