FOG02515
EOG84J117
EOG8BRV3D
EOG8C8694
EOG8CJT0P
EOG8GB5PG
sce:ARN1
Genes: 73
EOG84J117
EOG8BRV3D
EOG8C8694
EOG8CJT0P
EOG8GB5PG
sce:ARN1
Genes: 73
Protein description
other transporter
SGD Description
ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
PomBase Description
siderophore-iron transmembrane transporter Str1|siderophore-iron transporter Str2
AspGD Description
Ortholog(s) have ferrichrome transporter activity, siderophore uptake transmembrane transporter activity and role in cellular iron ion homeostasis, cellular response to drug, ferrichrome transport, transmembrane transport|Ortholog(s) have role in iron ion transmembrane transport, siderophore transmembrane transport and endoplasmic reticulum localization
References
Yun CW, et al. (2000 Apr 7). Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake.
Yun CW, et al. (2000 May 26). Siderophore-iron uptake in saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters.
Oberegger H, et al. (2002 Aug). Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization.
Haas H, et al. (2003 Apr 15). Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C.
Pelletier B, et al. (2003 Aug 1). Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system.
Moore RE, et al. (2003 May 13). The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae.
Haas H, et al. (2003 Sep). Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage.
Eisendle M, et al. (2004 Apr). Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Mercier A, et al. (2006 Nov). A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe.
Rustici G, et al. (2007). Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Lando D, et al. (2012). The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.
Chen Z, et al. (2012 Oct). A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Su Y, et al. (2017 Jan). Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
73 genes with posterior transmembrane prediction > 50% |
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FOG02516
EOG8GB5PG
sce:ARN2
Genes: 1
EOG8GB5PG
sce:ARN2
Genes: 1
SGD Description
Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
References
Heymann P, et al. (1999 Dec). Identification of a fungal triacetylfusarinine C siderophore transport gene (TAF1) in Saccharomyces cerevisiae as a member of the major facilitator superfamily.
Yun CW, et al. (2000 Apr 7). Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02517
EOG8GB5PG
sce:SIT1
Genes: 1
EOG8GB5PG
sce:SIT1
Genes: 1
SGD Description
Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
References
Lesuisse E, et al. (1998 Dec). Siderophore-mediated iron uptake in Saccharomyces cerevisiae: the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily.
Yun CW, et al. (2000 Apr 7). Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake.
Yun CW, et al. (2000 May 26). Siderophore-iron uptake in saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02518
EOG8GB5PG
sce:GEX1
Genes: 1
EOG8GB5PG
sce:GEX1
Genes: 1
SGD Description
Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog, GEX2, that arose from a segmental duplication
References
Gromadka R, et al. (1996 May). Subtelomeric duplications in Saccharomyces cerevisiae chromosomes III and XI: topology, arrangements, corrections of sequence and strain-specific polymorphism.
Sakaki K, et al. (2003 Sep). Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Dhaoui M, et al. (2011 Jun 15). Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02519
EOG8GB5PG
sce:GEX2
Genes: 1
EOG8GB5PG
sce:GEX2
Genes: 1
SGD Description
Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulation of the PKA pathway; GEX2 has a paralog, GEX1, that arose from a segmental duplication
References
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Dhaoui M, et al. (2011 Jun 15). Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02520
EOG8C8694
EOG8GB5PG
sce:ENB1
Genes: 13
EOG8C8694
EOG8GB5PG
sce:ENB1
Genes: 13
SGD Description
Endosomal ferric enterobactin transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
AspGD Description
Has domain(s) with predicted role in transmembrane transport and integral component of membrane localization|Siderophore-iron transporter|Has domain(s) with predicted role in transmembrane transport and integral component of membrane localization
References
Yun CW, et al. (2000 Apr 7). Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake.
Philpott CC, et al. (2002 Aug). The response to iron deprivation in Saccharomyces cerevisiae: expression of siderophore-based systems of iron uptake.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
13 genes with posterior transmembrane prediction > 50% |
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FOG02521
EOG8C8694
EOG8F1VJH
EOG8GB5PG
sce:absent
Genes: 6
EOG8C8694
EOG8F1VJH
EOG8GB5PG
sce:absent
Genes: 6
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
6 genes with posterior transmembrane prediction > 50% |
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FOG02522
EOG8C8694
sce:absent
Genes: 5
EOG8C8694
sce:absent
Genes: 5
AspGD Description
Ortholog(s) have role in ferric triacetylfusarinine C transport|Ortholog(s) have role in ferric triacetylfusarinine C transport
References
Oberegger H, et al. (2002 Aug). Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization.
Haas H, et al. (2003 Apr 15). Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C.
Haas H, et al. (2003 Sep). Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage.
Eisendle M, et al. (2004 Apr). Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans.
Eisendle M, et al. (2006 Oct). The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans.
Hortschansky P, et al. (2007 Jul 11). Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.
Peñalva MA, et al. (2008 Jun). Ambient pH gene regulation in fungi: making connections.
von Döhren H, et al. (2009 Mar). A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans.
de Souza WR, et al. (2013). Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans.
Dzikowska A, et al. (2015 Dec 1). KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
5 genes with posterior transmembrane prediction > 50% |
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FOG02523
EOG870S0C
EOG8F1VJH
sce:absent
Genes: 14
EOG870S0C
EOG8F1VJH
sce:absent
Genes: 14
PomBase Description
siderophore-iron transporter Str3
AspGD Description
Ortholog(s) have cytoplasm localization
References
Pelletier B, et al. (2003 Aug 1). Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system.
Mercier A, et al. (2006 Nov). A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe.
Rustici G, et al. (2007). Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Gabrielli N, et al. (2012 Dec 14). Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Su Y, et al. (2017 Jan). Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
14 genes with posterior transmembrane prediction > 50% |
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FOG02524
EOG8C8694
sce:absent
Genes: 1
EOG8C8694
sce:absent
Genes: 1
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02525
EOG8F1VJH
sce:absent
Genes: 1
EOG8F1VJH
sce:absent
Genes: 1
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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