FOG02413
EOG8XWDD2
sce:FET3
Genes: 37
EOG8XWDD2
sce:FET3
Genes: 37
SGD Description
Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
PomBase Description
iron transport multicopper oxidase Fio1
AspGD Description
Putative multicopper oxidase|Putative multicopper oxidase
References
Askwith C, et al. (1994 Jan 28). The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.
De Silva DM, et al. (1995 Jan 20). The FET3 gene product required for high affinity iron transport in yeast is a cell surface ferroxidase.
Askwith C, et al. (1997 Jan 3). An oxidase-permease-based iron transport system in Schizosaccharomyces pombe and its expression in Saccharomyces cerevisiae.
Hassett RF, et al. (1998 Sep 4). Spectral and kinetic properties of the Fet3 protein from Saccharomyces cerevisiae, a multinuclear copper ferroxidase enzyme.
Labbé S, et al. (1999 Dec 17). A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe.
Blackburn NJ, et al. (2000 Mar 7). Spectroscopic analysis of the trinuclear cluster in the Fet3 protein from yeast, a multinuclear copper oxidase.
Machonkin TE, et al. (2001 Jun 13). Spectroscopy and reactivity of the type 1 copper site in Fet3p from Saccharomyces cerevisiae: correlation of structure with reactivity in the multicopper oxidases.
Pelletier B, et al. (2002 Jun 21). Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe.
Palmer AE, et al. (2002 May 21). Spectroscopic characterization and O2 reactivity of the trinuclear Cu cluster of mutants of the multicopper oxidase Fet3p.
Pelletier B, et al. (2003 Aug 1). Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system.
Pelletier B, et al. (2005 Jul 1). Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe.
Taylor AB, et al. (2005 Oct 25). The copper-iron connection in biology: structure of the metallo-oxidase Fet3p.
Mander GJ, et al. (2006 Jul). Use of laccase as a novel, versatile reporter system in filamentous fungi.
Rustici G, et al. (2007). Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Levasseur A, et al. (2008 May). FOLy: an integrated database for the classification and functional annotation of fungal oxidoreductases potentially involved in the degradation of lignin and related aromatic compounds.
Pouliot B, et al. (2010 Jan). abc3+ encodes an iron-regulated vacuolar ABC-type transporter in Schizosaccharomyces pombe.
Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Kim KD, et al. (2011 May 20). Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast.
Gabrielli N, et al. (2012 Dec 14). Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.
Jacques JF, et al. (2014). Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation.
Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Mourer T, et al. (2015 Apr 17). Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe.
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Encinar del Dedo J, et al. (2015 Mar). A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast.
Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Su Y, et al. (2017 Jan). Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
36 genes with posterior transmembrane prediction > 50% |
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FOG02414
EOG8XWDD2
sce:FET5
Genes: 29
EOG8XWDD2
sce:FET5
Genes: 29
SGD Description
Multicopper oxidase; integral membrane protein with similarity to Fet3p; may have a role in iron transport
References
Spizzo T, et al. (1997 Nov). The yeast FET5 gene encodes a FET3-related multicopper oxidase implicated in iron transport.
Urbanowski JL, et al. (1999 Dec 31). The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
27 genes with posterior transmembrane prediction > 50% |
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FOG02415
EOG8VQ84J
EOG8XWDD2
sce:absent
Genes: 14
EOG8VQ84J
EOG8XWDD2
sce:absent
Genes: 14
AspGD Description
Putative multicopper oxidase|Dihydrogeodin oxidase
References
Mander GJ, et al. (2006 Jul). Use of laccase as a novel, versatile reporter system in filamentous fungi.
Levasseur A, et al. (2008 May). FOLy: an integrated database for the classification and functional annotation of fungal oxidoreductases potentially involved in the degradation of lignin and related aromatic compounds.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
6 genes with posterior transmembrane prediction > 50% |
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FOG02416
EOG8VQ84J
sce:absent
Genes: 1
EOG8VQ84J
sce:absent
Genes: 1
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02417
EOG8XWDD2
sce:absent
Genes: 2
EOG8XWDD2
sce:absent
Genes: 2
AspGD Description
Putative multicopper oxidase; required for wild-type black spore pigmentation; mutants produce light brown conidia and have reduced ornamention on the conidial cell surface
References
Mander GJ, et al. (2006 Jul). Use of laccase as a novel, versatile reporter system in filamentous fungi.
Levasseur A, et al. (2008 May). FOLy: an integrated database for the classification and functional annotation of fungal oxidoreductases potentially involved in the degradation of lignin and related aromatic compounds.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
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 |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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