FOG02324
EOG863XTZ

sce:CBF5

Genes: 33

SGD Description
Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs, on snRNA U2, and on some mRNAs; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs


PomBase Description
pseudouridylate synthase Cbf5 (predicted)


AspGD Description
Ortholog(s) have mRNA binding, pseudouridine synthase activity


References

Jiang W, et al. (1993 Aug). An essential yeast protein, CBF5p, binds in vitro to centromeres and microtubules.

Cadwell C, et al. (1997 Oct). The yeast nucleolar protein Cbf5p is involved in rRNA biosynthesis and interacts genetically with the RNA polymerase I transcription factor RRN3.

Watkins NJ, et al. (1998 Dec). Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Gar1p in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure.

Lafontaine DL, et al. (1998 Feb 15). The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase.

Winkler AA, et al. (1998 Jan 15). The lysine-rich C-terminal repeats of the centromere-binding factor 5 (Cbf5) of Kluyveromyces lactis are not essential for function.

Momany M, et al. (1999 Feb). Aspergillus nidulans swo mutants show defects in polarity establishment, polarity maintenance and hyphal morphogenesis.

Zebarjadian Y, et al. (1999 Nov). Point mutations in yeast CBF5 can abolish in vivo pseudouridylation of rRNA.

Mouaikel J, et al. (2002 Apr). Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus.

Fatica A, et al. (2002 Dec). Naf1 p is a box H/ACA snoRNP assembly factor.

Yang PK, et al. (2002 Nov 22). The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis.

Lin X, et al. (2003 Oct). The Aspergillus nidulans swoC1 mutant shows defects in growth and development.

Henras AK, et al. (2004 Nov). Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs.

Momany M, et al. (2004 Oct). The Aspergillus fumigatus cell wall is organized in domains that are remodelled during polarity establishment.

Sydorskyy Y, et al. (2005 Jun 15). Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Grenier St-Sauveur V, et al. (2013 Dec). Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Bernal M, et al. (2014 Jun). Proteome-wide search for PP2A substrates in fission yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%