FOG02305
EOG8QRFM9

sce:TYS1

Genes: 33

SGD Description
Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress


PomBase Description
cytoplasmic tyrosine-tRNA ligase Yrs1 (predicted)


AspGD Description
Ortholog(s) have cytosol localization


References

Faulhammer HG, et al. (1977 May 16). Tyroslyl-tRNA synthetase from baker's yeast. Rapid isolation by affinity elution, molecular weight of the enzyme, and determination of essential sulfhydryl groups.

Bare LA, et al. (1986 Sep 23). Specific substitution into the anticodon loop of yeast tyrosine transfer RNA.

Chow CM, et al. (1993 Jun 15). Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis.

Henry NL, et al. (1994 Dec 1). TFIIF-TAF-RNA polymerase II connection.

Guan MX, et al. (1997 Aug). Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae.

Sarkar S, et al. (1999 Dec 7). Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae.

Soutourina J, et al. (2000 Apr 21). D-tyrosyl-tRNA(Tyr) metabolism in Saccharomyces cerevisiae.

Fechter P, et al. (2000 Feb 22). Identity of tRNA for yeast tyrosyl-tRNA synthetase: tyrosylation is more sensitive to identity nucleotides than to structural features.

Dagkessamanskaia A, et al. (2001 Jun 12). Interaction of Knr4 protein, a protein involved in cell wall synthesis, with tyrosine tRNA synthetase encoded by TYS1 in Saccharomyces cerevisiae.

Azad AK, et al. (2001 May). Role of nuclear pools of aminoacyl-tRNA synthetases in tRNA nuclear export.

Ohno S, et al. (2001 Sep). Changing the amino acid specificity of yeast tyrosyl-tRNA synthetase by genetic engineering.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%