FOG02272
EOG808KSQ

sce:NCE103

Genes: 37

SGD Description
Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress


PomBase Description
carbonic anhydrase (predicted)


AspGD Description
Has domain(s) with predicted carbonate dehydratase activity, zinc ion binding activity and role in carbon utilization|Putative beta-type carbonic anhydrase


References

Cleves AE, et al. (1996 Jun). A new pathway for protein export in Saccharomyces cerevisiae.

Götz R, et al. (1999 Jul). Deletion of the carbonic anhydrase-like gene NCE103 of the yeast Saccharomyces cerevisiae causes an oxygen-sensitive growth defect.

Clark D, et al. (2004 May 1). Complementation of the yeast deletion mutant DeltaNCE103 by members of the beta class of carbonic anhydrases is dependent on carbonic anhydrase activity rather than on antioxidant activity.

Aguilera J, et al. (2005 Apr). Physiological and genome-wide transcriptional responses of Saccharomyces cerevisiae to high carbon dioxide concentrations.

Amoroso G, et al. (2005 Apr). The gene NCE103 (YNL036w) from Saccharomyces cerevisiae encodes a functional carbonic anhydrase and its transcription is regulated by the concentration of inorganic carbon in the medium.

Klengel T, et al. (2005 Nov 22). Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence.

Aguilera J, et al. (2005 Oct 15). Carbonic anhydrase (Nce103p): an essential biosynthetic enzyme for growth of Saccharomyces cerevisiae at atmospheric carbon dioxide pressure.

Murillo LA, et al. (2005 Sep). Genome-wide transcription profiling of the early phase of biofilm formation by Candida albicans.

Isik S, et al. (2008 Dec 15). Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Ramsdale M, et al. (2008 Oct). MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans.

Innocenti A, et al. (2008 Sep 15). Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.

Innocenti A, et al. (2009 Apr 1). Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates.

Innocenti A, et al. (2009 Jul 1). Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Innocenti A, et al. (2009 May 15). Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.

Teng YB, et al. (2009 Oct 24). Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103.

Güzel O, et al. (2010 Apr 15). Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.

Innocenti A, et al. (2010 Feb). Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.

Han KH, et al. (2010 Mar). The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans.

Singh RP, et al. (2011 Jul 15). Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.

Davis RA, et al. (2011 Mar 24). Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Vögtle FN, et al. (2012 Dec). Intermembrane space proteome of yeast mitochondria.

Cottier F, et al. (2012 Jan). The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast.

Monti SM, et al. (2012 Jan 15). Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02273
EOG808KSQ

sce:absent

Genes: 1

AspGD Description
Has domain(s) with predicted carbonate dehydratase activity, zinc ion binding activity and role in carbon utilization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%