FOG02195
EOG81ZCTR

sce:ISC1

Genes: 33

SGD Description
Inositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance


PomBase Description
inositol phosphosphingolipid phospholipase C, Css1


AspGD Description
Ortholog(s) have inositol phosphosphingolipid phospholipase activity and role in ceramide biosynthetic process, fungal-type cell wall polysaccharide biosynthetic process, response to salt stress, sphingolipid catabolic process


References

Sawai H, et al. (2000 Dec 15). Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae.

Feoktistova A, et al. (2001 Aug). Coordination between fission yeast glucan formation and growth requires a sphingolipase activity.

Todd BL, et al. (2006 Apr). Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Kashiwazaki J, et al. (2011 Oct). Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%