FOG02195
EOG81ZCTR
sce:ISC1
Genes: 33
SGD DescriptionInositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance
PomBase Descriptioninositol phosphosphingolipid phospholipase C, Css1
AspGD DescriptionOrtholog(s) have inositol phosphosphingolipid phospholipase activity and role in ceramide biosynthetic process, fungal-type cell wall polysaccharide biosynthetic process, response to salt stress, sphingolipid catabolic process
References
Sawai H, et al. (2000 Dec 15). Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae.
Feoktistova A, et al. (2001 Aug). Coordination between fission yeast glucan formation and growth requires a sphingolipase activity.
Todd BL, et al. (2006 Apr). Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Kashiwazaki J, et al. (2011 Oct). Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.
MojardÃn L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.