FOG02185
EOG8R7SSM

sce:AUR1

Genes: 38

SGD Description
Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase


PomBase Description
inositol phosphorylceramide synthase Aur1 (predicted)


AspGD Description
Ortholog(s) have inositol phosphoceramide synthase activity, role in establishment of cell polarity, mitotic G1 phase, sphingolipid biosynthetic process and Golgi apparatus localization


References

Heidler SA, et al. (1995 Dec). The AUR1 gene in Saccharomyces cerevisiae encodes dominant resistance to the antifungal agent aureobasidin A (LY295337).

Hashida-Okado T, et al. (1996 May 23). AUR1, a novel gene conferring aureobasidin resistance on Saccharomyces cerevisiae: a study of defective morphologies in Aur1p-depleted cells.

Nagiec MM, et al. (1997 Apr 11). Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.

Kuroda M, et al. (1999 Mar). An aureobasidin A resistance gene isolated from Aspergillus is a homolog of yeast AUR1, a gene responsible for inositol phosphorylceramide (IPC) synthase activity.

Heidler SA, et al. (2000 Jan 3). Inositol phosphoryl transferases from human pathogenic fungi.

Levine TP, et al. (2000 Jul). Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae.

Cheng J, et al. (2001 Sep). Cell cycle progression and cell polarity require sphingolipid biosynthesis in Aspergillus nidulans.

Momany M, et al. (2002 Dec). Polarity in filamentous fungi: establishment, maintenance and new axes.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Aeed PA, et al. (2009 Feb). Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A.

Morita H, et al. (2009 Nov). Heterologous expression and characterization of CpI, OcpA, and novel serine-type carboxypeptidase OcpB from Aspergillus oryzae.

Sato K, et al. (2009 Oct). Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 38 genes with posterior transmembrane prediction > 50%

FOG02186
EOG8DZ09S
EOG8R7SSM

sce:IPT1

Genes: 25

SGD Description
Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin


References

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 25 genes with posterior transmembrane prediction > 50%

FOG02187
EOG8DZ09S

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%