FOG02179
EOG82283C

sce:LAC1;LAG1

Genes: 37

SGD Description
Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication|Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enahnces invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication


PomBase Description
sphingosine N-acyltransferase Lac1


AspGD Description
Ceramide synthase


References

Amatruda JF, et al. (1992 Dec). Effects of null mutations and overexpression of capping protein on morphogenesis, actin distribution and polarized secretion in yeast.

D'mello NP, et al. (1994 Jun 3). Cloning and characterization of LAG1, a longevity-assurance gene in yeast.

Barz WP, et al. (1999 Apr). Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins.

Guillas I, et al. (2001 Jun 1). C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p.

Schorling S, et al. (2001 Nov). Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae.

Winter E, et al. (2002 Aug). TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?

Kolaczkowski M, et al. (2004 Aug). Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae.

Jiang JC, et al. (2004 Jul). Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Vallée B, et al. (2005 Feb 23). Lip1p: a novel subunit of acyl-CoA ceramide synthase.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Li S, et al. (2006 Mar). Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans.

Kageyama-Yahara N, et al. (2006 Sep 15). Transmembrane topology of ceramide synthase in yeast.

Li S, et al. (2007 May). basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 37 genes with posterior transmembrane prediction > 50%

FOG02180
EOG82283C

sce:absent

Genes: 30

PomBase Description
sphingosine N-acyltransferase Lag1


AspGD Description
Ortholog(s) have sphingosine N-acyltransferase activity and role in filamentous growth of a population of unicellular organisms, glycosylceramide biosynthetic process, unidimensional cell growth, vacuolar acidification

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 30 genes with posterior transmembrane prediction > 50%

FOG02181
EOG82283C

sce:absent

Genes: 1

AspGD Description
Ortholog(s) have sphingosine N-acyltransferase activity and role in ceramide biosynthetic process


References

Li S, et al. (2006 Mar). Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans.

Li S, et al. (2007 May). basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Li S, et al. (2009 Mar-Apr). Induction of cell wall thickening by the antifungal compound dihydromaltophilin disrupts fungal growth and is mediated by sphingolipid biosynthesis.

Colabardini AC, et al. (2013). Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%