FOG02175
EOG8HMGTC

sce:LCB3;YSR3

Genes: 34

SGD Description
Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication|Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication


PomBase Description
sphingosine-1-phosphate phosphatase


AspGD Description
Has domain(s) with predicted catalytic activity and membrane localization


References

Wiesenberger G, et al. (1991 Jan 5). MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family.

Qie L, et al. (1997 Jun 27). Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids.

Mao C, et al. (1997 Nov 7). Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase.

Mandala SM, et al. (1998 Jan 6). Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.

Mao C, et al. (1999 Sep 15). The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses.

Mao C, et al. (2000). Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging.

Zanolari B, et al. (2000 Jun 15). Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae.

Birchwood CJ, et al. (2001 Apr 13). Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation.

Ferguson-Yankey SR, et al. (2002 May). Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast.

Kobayashi SD, et al. (2003 Apr). Ceramide/long-chain base phosphate rheostat in Saccharomyces cerevisiae: regulation of ceramide synthesis by Elo3p and Cka2p.

Funato K, et al. (2003 Feb 28). Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae.

Kihara A, et al. (2003 Jun). Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%