FOG02156
EOG8FQZ6M

sce:PLC1

Genes: 32

SGD Description
Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation


PomBase Description
phosphoinositide phospholipase C Plc1


AspGD Description
Ortholog(s) have phospholipase C activity, role in cellular response to UV, filamentous growth of a population of unicellular organisms, regulation of nuclear division and cytosol, nucleus localization


References

Payne WE, et al. (1993 Jul). A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.

Yoko-o T, et al. (1993 Mar 1). The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growth.

Flick JS, et al. (1993 Sep). Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae.

Lin H, et al. (2002 May). Phospholipase C interacts with Sgd1p and is required for expression of GPD1 and osmoresistance in Saccharomyces cerevisiae.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Vanzela AP, et al. (2011 Jul). Phosphatidylinositol phospholipase C mediates carbon sensing and vegetative nuclear duplication rates in Aspergillus nidulans.

Ahn CS, et al. (2014 Jul). The observation of plcA mutation and localization in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%