FOG02137
EOG8KKWHZ

sce:STT4

Genes: 35

SGD Description
Phosphatidylinositol-4-kinase; functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization


PomBase Description
1-phosphatidylinositol 4-kinase Stt4 (predicted)


AspGD Description
Ortholog(s) have 1-phosphatidylinositol 4-kinase activity, role in establishment or maintenance of cell polarity, invasive filamentous growth, phosphatidylinositol phosphorylation and cytosol, mitochondrion, plasma membrane localization


References

Yoshida S, et al. (1994 Jan 14). A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 19 genes with posterior transmembrane prediction > 50%

FOG02138
EOG8KKWHZ

sce:PIK1

Genes: 32

SGD Description
Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; may control nonselective autophagy and mitophagy through trafficking of Atg9p


PomBase Description
1-phosphatidylinositol 4-kinase Pik1


References

Flanagan CA, et al. (1993 Nov 26). Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability.

Garcia-Bustos JF, et al. (1994 May 15). PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus.

Hendricks KB, et al. (1999 Aug). Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase.

Hull CM, et al. (1999 Aug 20). Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.

Desautels M, et al. (2001 Feb 23). Cdc4p, a contractile ring protein essential for cytokinesis in Schizosaccharomyces pombe, interacts with a phosphatidylinositol 4-kinase.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Strahl T, et al. (2007 Oct 19). Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1).

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Lim S, et al. (2011 Apr 8). Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast.

Sammons MR, et al. (2011 Jul 15). A calmodulin-related light chain from fission yeast that functions with myosin-I and PI 4-kinase.

Malecki M, et al. (2013 Jul 3). The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 14 genes with posterior transmembrane prediction > 50%