FOG02134
EOG8GHX4D

sce:VPS34

Genes: 33

SGD Description
Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery


PomBase Description
phosphatidylinositol 3-kinase Pik3


AspGD Description
1-phosphatidylinositol 3-kinase/phosphoinositide 3-kinase


References

Robinson JS, et al. (1988 Nov). Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

Auger KR, et al. (1989 Dec 5). Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae.

Herman PK, et al. (1990 Dec). Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.

Schu PV, et al. (1993 Apr 2). Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.

Stack JH, et al. (1993 May). A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.

Stack JH, et al. (1994 Dec 16). Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.

Munn AL, et al. (1994 Oct). Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.

Kimura K, et al. (1995 Apr). Phosphatidylinositol-3 kinase in fission yeast: a possible role in stress responses.

Takegawa K, et al. (1995 Dec). Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology.

Takahashi T, et al. (2001 Aug). Identification of genes required for growth under ethanol stress using transposon mutagenesis in Saccharomyces cerevisiae.

Kihara A, et al. (2001 Feb 5). Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.

Burda P, et al. (2002 Oct 15). Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.

Onishi M, et al. (2003 Feb). Role of phosphatidylinositol 3-phosphate in formation of forespore membrane in Schizosaccharomyces pombe.

Takegawa K, et al. (2003 Nov 7). Identification of a SNARE protein required for vacuolar protein transport in Schizosaccharomyces pombe.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Mitra P, et al. (2004 Jul 19). A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.

Koga T, et al. (2004 Jun). Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe.

Chikashige Y, et al. (2006 Apr 7). Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Onishi M, et al. (2007 Dec). Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation.

Abenza JF, et al. (2010 Aug 1). Aspergillus RabB Rab5 integrates acquisition of degradative identity with the long distance movement of early endosomes.

Idiris A, et al. (2010 Jan). Enhanced protein secretion from multiprotease-deficient fission yeast by modification of its vacuolar protein sorting pathway.

Hosomi A, et al. (2011 Oct). Schizosaccharomyces pombe Pep12p is required for vacuolar protein transport and vacuolar homotypic fusion.

Lee JH, et al. (2012). The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Araki Y, et al. (2013 Oct 28). Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity.

Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Hosomi A, et al. (2015 Jan). Vsl1p cooperates with Fsv1p for vacuolar protein transport and homotypic fusion in Schizosaccharomyces pombe.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Hoya M, et al. (2017 Feb). Traffic Through the Trans-Golgi Network and the Endosomal System Requires Collaboration Between Exomer and Clathrin Adaptors in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%